Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16466248 | 0.88 | FFAR4 (0.50) | USP2SMN1; SMN2RECQLFFAR4KDM4E | |
| SCHEMBL31270732 | 0.86 | USP2 (0.43) | USP2SMN1; SMN2RECQLHPGDEPHX2 | |
| SCHEMBL16465129 | 0.82 | FFAR4 (0.50) | USP2SMN1; SMN2RECQLFFAR4KDM4E | |
| SCHEMBL5765422 | 0.81 | USP2 (0.48) | USP2SMN1; SMN2RECQLKDM4EDDB1 | |
| SCHEMBL24753619 | 0.80 | USP2 (0.47) | USP2SMN1; SMN2RECQLKDM4EHPGD | |
| SCHEMBL31693860 | 0.80 | GPR119 (0.49) | FFAR4KDM4EPKMDDB1CRBN | |
| SCHEMBL6749163 | 0.78 | GPR119 (0.52) | USP2SMN1; SMN2KDM4EPKMDDB1 | |
| SCHEMBL20396172 | 0.78 | USP2 (0.44) | USP2SMN1; SMN2RECQLHPGDEPHX2 | |
| SCHEMBL20396156 | 0.78 | NR1H2 (0.48) | USP2SMN1; SMN2RECQLEPHX2GPR119 | |
| SCHEMBL18053621 | 0.77 | USP2 (0.59) | USP2SMN1; SMN2RECQLHPGDEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012009217-A1 | SPIROCYCLIC COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2012-01-19 | — | — | WO | disclosed |