Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 1/20 | 0.46 |
| ▸ | PADI4 | Q9UM07 | 5/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6351855 | 0.88 | PADI4 (0.50) | PADI4ALDH1A1 | |
| SCHEMBL6350424 | 0.88 | MAPT (0.43) | FASNPADI4MAPK14CDK5CDK5R1 | |
| SCHEMBL6352443 | 0.82 | MAPK14 (0.43) | PADI4MAPK14CDK5CDK5R1GRIN2D | |
| SCHEMBL998426 | 0.78 | PDE2A (0.52) | FASNPADI4MAPK14CDK5CDK5R1 | |
| SCHEMBL6884723 | 0.74 | FASN (0.40) | FASNPADI4MAPK14CDK5CDK5R1 | |
| SCHEMBL6825080 | 0.70 | MAPK14 (0.52) | PADI4MAPK14CYP11B1CYP11B2PARP1 | |
| SCHEMBL932818 | 0.69 | CYP2E1 (0.52) | PADI4MAPK14CDK5CDK5R1KDM4E | |
| SCHEMBL962621 | 0.68 | PDE2A (0.55) | MAPK14CDK5CDK5R1GRIN2DGRIN3B | |
| SCHEMBL29455656 | 0.67 | CYP2A6 (0.58) | CDK5KDM4EALDH1A1CYP11B1CYP11B2 | |
| SCHEMBL17227623 | 0.67 | CYP2A6 (0.58) | CDK5KDM4EALDH1A1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120115885-A1 | Quinolinone PDE2 Inhibitors | MERCK SHARP & DOHME LLC | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120115885-A1 | Quinolinone PDE2 Inhibitors | PDE12, PDE2A, PDE4A | FASN 3427/4885PADI4 494/4885MAPK14 2536/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.