Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | FASN | P49327 | 1/20 | 0.41 |
| ▸ | PDE9A | O76083 | 2/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | PADI4 | Q9UM07 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | CTSV | O60911 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10146697 | 0.88 | FASN (0.46) | FASNCDK5CDK5R1MAPK14HPGD | |
| SCHEMBL6352443 | 0.82 | MAPK14 (0.43) | CDK5CDK5R1MAPK14PADI4 | |
| SCHEMBL6351855 | 0.81 | PADI4 (0.50) | MAPTMAPK1HTTPADI4MEN1 | |
| SCHEMBL957899 | 0.74 | PDE2A (0.53) | MAPTFASNPDE9ACDK5CDK5R1 | |
| SCHEMBL28132803 | 0.71 | MAPT (0.71) | MAPTPDE9ACDK5CDK5R1MAPK14 | |
| SCHEMBL962621 | 0.68 | PDE2A (0.55) | CDK5CDK5R1MAPK14MMP2MMP9 | |
| SCHEMBL6825380 | 0.64 | MAPT (0.65) | MAPTFASNPDE9ACDK5CDK5R1 | |
| SCHEMBL935270 | 0.64 | PDE2A (0.48) | MAPTPDE9ACDK5CDK5R1MAPK14 | |
| SCHEMBL20227594 | 0.63 | PARP1 (0.63) | MAPTPDE9AHPGDMAPK1HTT | |
| SCHEMBL21636104 | 0.63 | PARP1 (0.63) | MAPTPDE9AHPGDMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120115885-A1 | Quinolinone PDE2 Inhibitors | MERCK SHARP & DOHME LLC | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120115885-A1 | Quinolinone PDE2 Inhibitors | PDE12, PDE2A, PDE4A | MAPT 1502/4885FASN 3427/4885PDE9A 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.