Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R2 | O00459 | 10/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 13/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.33 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1695065 | 0.91 | PIK3R2 (0.45) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL1695063 | 0.91 | PIK3R2 (0.45) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL10146911 | 0.83 | HPGD (0.46) | PIK3CD | |
| SCHEMBL10146906 | 0.83 | PIK3CD (0.41) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL1695113 | 0.77 | PIK3R2 (0.44) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL10147628 | 0.77 | PIK3CD (0.54) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL1695133 | 0.77 | PIK3CD (0.54) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL1695308 | 0.76 | PIK3CD (0.50) | PIK3R2PIK3CDPIK3CGPIK3R1 | |
| SCHEMBL10146932 | 0.76 | PIK3CD (0.50) | PIK3R2PIK3CDPIK3CGPIK3R1 | |
| SCHEMBL1695602 | 0.74 | PIK3CD (0.52) | PIK3R2PIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012003274-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |