Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 16/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10146482 | 0.79 | DGAT1 (0.88) | DGAT1CYP2C9KCNH2NPY5R | |
| SCHEMBL10146541 | 0.77 | DGAT1 (0.71) | DGAT1CYP2C9KCNH2 | |
| SCHEMBL10147264 | 0.69 | DGAT1 (0.60) | DGAT1CYP2C9KCNH2 | |
| SCHEMBL6998692 | 0.69 | DGAT1 (0.48) | DGAT1KCNH2 | |
| SCHEMBL14235543 | 0.68 | DGAT1 (0.51) | DGAT1CYP2C9KCNH2 | |
| SCHEMBL10147085 | 0.68 | DGAT1 (0.58) | DGAT1CYP2C9KCNH2 | |
| SCHEMBL14952343 | 0.68 | DGAT1 (0.51) | DGAT1CYP2C9KCNH2 | |
| SCHEMBL6994611 | 0.67 | DGAT1 (0.42) | DGAT1KCNH2 | |
| SCHEMBL6992350 | 0.67 | DGAT1 (0.44) | DGAT1CYP2C9KCNH2 | |
| SCHEMBL14235402 | 0.67 | DGAT1 (0.50) | DGAT1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012009217-A1 | SPIROCYCLIC COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2012-01-19 | — | — | WO | disclosed |