Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 20/20 | 0.66 |
| ▸ | PIK3CB | P42338 | 20/20 | 0.66 |
| ▸ | PIK3CG | P48736 | 20/20 | 0.66 |
| ▸ | PIK3CA | P42336 | 18/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10147638 | 0.91 | PIK3CD (0.79) | PIK3CDPIK3CBPIK3CGPIK3CACYP2D6 | |
| SCHEMBL1694734 | 0.89 | PIK3CD (0.79) | PIK3CDPIK3CBPIK3CGPIK3CACYP2D6 | |
| SCHEMBL10147635 | 0.89 | PIK3CD (0.70) | PIK3CDPIK3CBPIK3CGPIK3CACYP2D6 | |
| SCHEMBL3845417 | 0.88 | PIK3CD (0.84) | PIK3CDPIK3CBPIK3CGPIK3CACYP2D6 | |
| SCHEMBL2717338 | 0.88 | PIK3CD (0.84) | PIK3CDPIK3CBPIK3CGPIK3CACYP2D6 | |
| SCHEMBL1695311 | 0.87 | PIK3CD (0.71) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL1695294 | 0.86 | PIK3CD (0.70) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL1694906 | 0.85 | PIK3CD (0.77) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL1695071 | 0.84 | PIK3CD (0.77) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL1694666 | 0.83 | PIK3CD (0.49) | PIK3CDPIK3CBPIK3CGPIK3CACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130085131-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2013-04-04 | — | — | US | disclosed |
| US-20130085131-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2013-04-04 | — | — | US | disclosed |
| US-20130085131-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2013-04-04 | — | — | US | disclosed |
| WO-2012003274-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130085131-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | MCL1, SSB, BCL9 | PIK3CD 1181/4885PIK3CB 1532/4885PIK3CG 2150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.