Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 17/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 17/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 17/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 15/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1695119 | 0.91 | PIK3CD (0.60) | PIK3CDPIK3CBPIK3CGPIK3CACYP2D6 | |
| SCHEMBL1694855 | 0.89 | PIK3CD (0.52) | PIK3CDPIK3CBPIK3CGPIK3CACYP2D6 | |
| SCHEMBL1695164 | 0.89 | PIK3CD (0.59) | PIK3CDPIK3CBPIK3CGPIK3CACYP2D6 | |
| SCHEMBL2717340 | 0.87 | PIK3CD (0.60) | PIK3CDPIK3CBPIK3CGPIK3CACYP2D6 | |
| SCHEMBL1695313 | 0.87 | PIK3CD (0.50) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL1695295 | 0.86 | PIK3CD (0.49) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL1695299 | 0.85 | PIK3CD (0.56) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL1695073 | 0.84 | PIK3CD (0.56) | PIK3CDPIK3CBPIK3CGPIK3CACDK1 | |
| SCHEMBL10147539 | 0.83 | PIK3CD (0.66) | PIK3CDPIK3CBPIK3CGPIK3CACYP2D6 | |
| SCHEMBL1694664 | 0.81 | PIK3CD (0.47) | PIK3CDPIK3CBPIK3CGPIK3CACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588467-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | Amgen Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003274-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |