Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 7/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | G6PD | P11413 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.42 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.42 |
| ▸ | TRPM4 | Q8TD43 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1016386 | 0.99 | SERPINE1 (0.55) | SERPINE1POLBG6PDKDM4EGAA | |
| SCHEMBL1014763 | 0.98 | SERPINE1 (0.54) | SERPINE1POLBG6PDKDM4EGAA | |
| SCHEMBL1015514 | 0.89 | SERPINE1 (0.44) | SERPINE1POLBG6PDKDM4EGAA | |
| SCHEMBL1014762 | 0.89 | SERPINE1 (0.44) | SERPINE1POLBG6PDGAAMEN1 | |
| SCHEMBL1797569 | 0.80 | SERPINE1 (0.56) | SERPINE1POLBG6PDKDM4EGAA | |
| SCHEMBL22468222 | 0.79 | SERPINE1 (0.75) | SERPINE1POLBG6PDKDM4EGAA | |
| SCHEMBL1015946 | 0.79 | SERPINE1 (0.54) | SERPINE1POLBG6PDKDM4EGAA | |
| SCHEMBL1016298 | 0.79 | SERPINE1 (0.54) | SERPINE1POLBG6PDKDM4EGAA | |
| SCHEMBL29492572 | 0.78 | SERPINE1 (0.77) | SERPINE1POLBG6PDKDM4EGAA | |
| SCHEMBL1016107 | 0.78 | SERPINE1 (0.77) | SERPINE1POLBG6PDKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2990057-B1 | PAI-1 INHIBITOR FOR USE IN ENHANCING THE ANTITUMOR EFFECT OF AN ANTITUMOR AGENT IN A PATIENT | RENASCIENCE CO LTD (JP) | 2019-03-20 | — | — | EP | disclosed |
| EP-2990057-A1 | NOVEL USE FOR PAI-1 INHIBITOR | Renascience Co., Ltd. (JP) | 2016-03-02 | — | — | EP | disclosed |
| EP-2272822-A1 | INHIBITOR OF PLASMINOGEN ACTIVATOR INHIBITOR-1 | Renascience CO., LTD. (JP) | 2011-01-12 | — | — | EP | disclosed |