Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 6/20 | 0.54 |
| ▸ | CNR1 | P21554 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | G6PD | P11413 | 1/20 | 0.52 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.49 |
| ▸ | MGLL | Q99685 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1015100 | 0.99 | SERPINE1 (0.55) | SERPINE1CNR1POLBG6PDGRIK1 | |
| SCHEMBL1015135 | 0.91 | GRIK1 (0.51) | SERPINE1POLBG6PDGRIK1KDM4E | |
| SCHEMBL1015269 | 0.90 | GRIK1 (0.52) | SERPINE1POLBG6PDGRIK1KDM4E | |
| SCHEMBL1015947 | 0.89 | CNR1 (0.51) | SERPINE1CNR1POLBG6PDGRIK1 | |
| SCHEMBL1015837 | 0.89 | CNR1 (0.51) | SERPINE1CNR1POLBG6PDMGLL | |
| SCHEMBL1015739 | 0.88 | SERPINE1 (0.53) | SERPINE1CNR1POLBG6PDGRIK1 | |
| SCHEMBL1016298 | 0.88 | SERPINE1 (0.54) | SERPINE1CNR1POLBG6PDGRIK1 | |
| SCHEMBL1014958 | 0.87 | SERPINE1 (0.55) | SERPINE1CNR1POLBG6PDGRIK1 | |
| SCHEMBL1019407 | 0.87 | SERPINE1 (0.54) | SERPINE1CNR1POLBG6PDGRIK1 | |
| SCHEMBL1016300 | 0.86 | SERPINE1 (0.54) | SERPINE1CNR1POLBG6PDGRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2990057-B1 | PAI-1 INHIBITOR FOR USE IN ENHANCING THE ANTITUMOR EFFECT OF AN ANTITUMOR AGENT IN A PATIENT | RENASCIENCE CO LTD (JP) | 2019-03-20 | — | — | EP | disclosed |
| EP-2272822-A1 | INHIBITOR OF PLASMINOGEN ACTIVATOR INHIBITOR-1 | Renascience CO., LTD. (JP) | 2011-01-12 | — | — | EP | disclosed |