Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 15/20 | 0.48 |
| ▸ | PIK3R2 | O00459 | 14/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.48 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1694945 | 0.93 | PIK3CD (0.50) | PIK3CDPIK3R2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL14815289 | 0.93 | PIK3CD (0.50) | PIK3CDPIK3R2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL10147661 | 0.91 | PIK3CD (0.52) | PIK3CDPIK3R2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL1695240 | 0.91 | PIK3CD (0.52) | PIK3CDPIK3R2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL10147628 | 0.90 | PIK3CD (0.54) | PIK3CDPIK3R2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL1695133 | 0.90 | PIK3CD (0.54) | PIK3CDPIK3R2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL14815738 | 0.90 | PIK3CD (0.53) | PIK3CDPIK3R2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL14815737 | 0.90 | PIK3CD (0.53) | PIK3CDPIK3R2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL1695360 | 0.87 | PIK3R2 (0.52) | PIK3CDPIK3R2PIK3CG | |
| SCHEMBL10147643 | 0.87 | PIK3R2 (0.52) | PIK3CDPIK3R2PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012003274-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |