Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALB | P02768 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | PDE4A | P27815 | 1/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.53 |
| ▸ | SHH | Q15465 | 1/20 | 0.53 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.53 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.53 |
| ▸ | SMO | Q99835 | 1/20 | 0.53 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.53 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1018796 | 0.91 | ALB (0.55) | ALBHTR1ASLC6A2PDE4AOPRM1 | |
| SCHEMBL2611874 | 0.87 | ALB (0.58) | ALBHTR1ASLC6A2PDE4AOPRM1 | |
| SCHEMBL1017948 | 0.87 | USP28 (0.55) | ALBHTR1ASLC6A2PDE4AOPRM1 | |
| SCHEMBL27707351 | 0.87 | ALB (0.51) | ALBHTR1ASLC6A2PDE4AOPRM1 | |
| SCHEMBL28386672 | 0.86 | ALB (0.64) | ALBHTR1ASLC6A2PDE4AOPRM1 | |
| SCHEMBL27688097 | 0.86 | USP28 (0.57) | ALBHTR1ASLC6A2PDE4AOPRM1 | |
| SCHEMBL1019369 | 0.86 | USP28 (0.60) | ALBHTR1ASLC6A2PDE4AOPRM1 | |
| SCHEMBL1015388 | 0.85 | ALB (0.53) | ALBHTR1ASLC6A2PDE4AOPRM1 | |
| SCHEMBL15424139 | 0.84 | ALB (0.59) | ALBHTR1ASLC6A2PDE4AOPRM1 | |
| SCHEMBL1017518 | 0.84 | ALB (0.59) | ALBHTR1ASLC6A2PDE4AOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102964294-A | Pyridyl inhibitors of hedgehog signalling | GENENTECH INC | 2013-03-13 | — | — | CN | disclosed |
| CN-102083822-A | Pyridyl inhibitors of HEDGEHOG signalling | GENENTECH INC | 2011-06-01 | — | — | CN | disclosed |
| EP-2271642-A2 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | Genentech, Inc. (US) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009126863-A2 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2009-10-15 | — | — | WO | disclosed |
| CN-101072755-A | Pyridyl inhibitors of Hedgehog signaling | GENENTECH INC (US) | 2007-11-14 | — | — | CN | disclosed |
| EP-1789390-A2 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | Genentech, Inc. (US) | 2007-05-30 | — | — | EP | disclosed |
| WO-2006028958-A2 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2006-03-16 | — | — | WO | disclosed |