USP28 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1259325	0.66	13/20
SCHEMBL1625019	0.64	13/20
SCHEMBL2221108	0.56	13/20
SCHEMBL1625829	0.52	13/20
SCHEMBL1624570	0.51	13/20
SCHEMBL1624585	0.50	13/20
SCHEMBL2223513	0.55	12/20
SCHEMBL2262561	0.52	11/20
SCHEMBL2222068	0.49	11/20
Vismodegib (SCHEMBL302587)	1.00	9/20
Vismodegib (SCHEMBL1017957)	0.98	9/20
SCHEMBL1258699	0.82	9/20
SCHEMBL1990768	0.48	9/20
SCHEMBL1014723	0.83	8/20
SCHEMBL1019227	0.83	8/20
SCHEMBL1258906	0.83	8/20
SCHEMBL1021007	0.74	8/20
SCHEMBL1259359	0.71	8/20
SCHEMBL1457879	0.49	8/20
SCHEMBL1016538	0.85	7/20

Clinical trials — most relevant to USP28 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors on Sarcopenia in Hemodialysis Patients	PHASE4	NOT_YET_RECRUITING
Can We Achieve 'high-quality' Weight Loss Through Supplementation and Exercise? the TRIM MUSCLE Study	PHASE3	COMPLETED
Desferal Administration to Improve the Impaired Reaction to Hypoxia in Diabetes	PHASE2	UNKNOWN
Alrizomadlin (APG-115) in Subjects With BAP1 Cancer Syndrome and Early-Stage Mesothelioma	PHASE2	WITHDRAWN
Relapsed and/or Refractory Non-Hodgkin Lymphoma Study	PHASE2	WITHDRAWN
Decitabine/Cedazuridine (INQOVI), an Oral DNA Demethylating Agent, in Subjects With BAP1 Cancer Predisposition Syndrome and Subclinical, Early-Stage Mesothelioma	PHASE2	SUSPENDED
Effect of Deferoxamine on Wound Healing Rate in Patients With Diabetes Foot Ulcers	PHASE2	NOT_YET_RECRUITING
The Effect of Roxadustat on Renal Oxygenation in Diabetes Nephropathy	PHASE2	NOT_YET_RECRUITING
MLN9708 and Dexamethasone for High-Risk Smoldering Multiple Myeloma	PHASE2	WITHDRAWN
Studying TAK-243 in Patients With Advanced Cancer	PHASE1	RECRUITING
PS-341 and Radiation to Treat Advanced Cancer of the Head and Neck	PHASE1	COMPLETED
Testing the Safety of CB-5339 in Patients With Cancer	PHASE1	WITHDRAWN
Study of Patients With Stage IV Malignant Melanoma Using PS-341 (Bortezomib, Velcade) and Interferon-alpha-2b in Malignant Melanoma	PHASE1	COMPLETED
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis	nan	UNKNOWN
Diagnostic Potential of UCHL1 in Acute Decompensated Heart Failure	nan	COMPLETED
Long Term Follow-Up of Patients With Mesothelioma and Individuals With Germline Mutations in BAP1	nan	RECRUITING
The Role of RING Ubiquitin Ligases in Biologic and Oncologic Processes in Tissues of Mesenchymal Origin	nan	UNKNOWN
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men	nan	RECRUITING
Clinical Study of 68Ga-DOTA-BLP PET Imaging in Noninvasive Diagnosis of Malignant Tumors	nan	NOT_YET_RECRUITING
Biomarkers in Tumor Samples From Younger Patients With Neuroblastoma	nan	COMPLETED
Cytomegalovirus (CMV) MicroRNA Expression in Vivo and Immune Evasion Correlates	nan	COMPLETED
Low Dose Melphalan and Bortezomib for AML and High-Risk MDS	nan	COMPLETED
Evaluation of Prognostic Factors: From Breast Cancer to Bone Metastases	nan	UNKNOWN
Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients With BAP1 Tumor Predisposition Syndrome	nan	RECRUITING
Inhibition of SENP1 for the Suppression of OS Growth and Metastasis	nan	UNKNOWN
The PREServation of MUScle Function in Critically Ill Patients (PRESMUS)	nan	UNKNOWN
NLRP3 Inflammasome and Physical Therapy in ICU-Acquired Weakness	nan	RECRUITING
A Natural History Study of Angelman Syndrome	nan	RECRUITING
Exercise Therapy to Reduce Heart Failure Symptoms; Sorting Mechanisms of Benefit	nan	COMPLETED
Relationship Between Nutritional State and Respiratory Muscle Weakness in Adult Patients With Bronchietasis	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a USP28 binder may also engage these)

Protein	Name	Similarity
Q5I043	—	1.000	Q5I043 →
D3ZJ96	—	1.000	D3ZJ96 →
P57080	—	0.997	P57080 →
Q5ZID5	—	0.995	Q5ZID5 →
Q9LYZ7	—	0.992	Q9LYZ7 →
Q92562	—	0.992	Q92562 →
Q86UV5	—	0.992	Q86UV5 →
Q6ZPS6	—	0.991	Q6ZPS6 →
Q5ICL9	—	0.991	Q5ICL9 →
Q12242	—	0.991	Q12242 →
Q9SUG7	—	0.991	Q9SUG7 →
A8E7C5	—	0.991	A8E7C5 →
Q9FY74	—	0.991	Q9FY74 →
Q6DDJ5	—	0.991	Q6DDJ5 →
Q9Y2H2	—	0.991	Q9Y2H2 →
Q94C95	—	0.990	Q94C95 →
Q6Q4D0	—	0.990	Q6Q4D0 →
Q6GM53	—	0.990	Q6GM53 →
P93002	—	0.990	P93002 →
B2GUY1	—	0.990	B2GUY1 →
Q3V0C5	—	0.990	Q3V0C5 →
F4IGA5	—	0.990	F4IGA5 →
Q811U4	—	0.990	Q811U4 →
Q7Z3E5	—	0.990	Q7Z3E5 →
Q1L8G6	—	0.990	Q1L8G6 →
Q80U87	—	0.990	Q80U87 →
Q08AX9	—	0.990	Q08AX9 →
Q9M086	—	0.990	Q9M086 →
P93042	—	0.989	P93042 →
Q5JCS6	—	0.989	Q5JCS6 →