Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.48 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.48 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.48 |
| ▸ | PLG | P00747 | 1/20 | 0.47 |
| ▸ | PLAT | P00750 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 3/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14013458 | 1.00 | CYP2D6 (0.56) | CYP2D6TDP1TPSAB1TPSD1TPSG1 | |
| Tranexamic Acid SCHEMBL2569232 | 0.89 | PLG (0.67) | CYP2D6TDP1TPSAB1TPSD1TPSG1 | |
| SCHEMBL48633 | 0.89 | — | — | |
| SCHEMBL13165688 | 0.89 | TDP1 (0.58) | CYP2D6TDP1CACNA1HNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL4553435 | 0.87 | — | — | |
| SCHEMBL10106981 | 0.83 | TDP1 (0.52) | CYP2D6TDP1CACNA1HNPC1RAB9A | |
| SCHEMBL10147959 | 0.81 | CYP2D6 (0.50) | CYP2D6TDP1TPSAB1TPSD1TPSG1 | |
| SCHEMBL23136944 | 0.81 | TDP1 (0.50) | CYP2D6TDP1CACNA1HALOX15EPHX1 | |
| SCHEMBL14438969 | 0.81 | TDP1 (0.50) | CYP2D6TDP1CACNA1HNPC1RAB9A | |
| SCHEMBL4761476 | 0.81 | TDP1 (0.50) | CYP2D6TDP1CACNA1HALOX15EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106131-B2 | Hydrolytically stable maleimide-terminated polymers | NEKTAR THERAPEUTICS (US) | 2012-01-31 | — | — | US | disclosed |
| US-20090012241-A1 | Hydrolytically stable maleimide-terminated polymers | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2009-01-08 | — | — | US | disclosed |
| US-7432331-B2 | Hydrolytically stable maleimide-terminated polymers | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2008-10-07 | — | — | US | disclosed |