Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tranexamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG known ✓ | P00747 | 1/20 | 0.67 |
| ▸ | PLAT | P00750 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.42 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.42 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ANPEP | P15144 | 1/20 | 0.39 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | VCP | P55072 | 3/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680676 | 0.91 | PLG (0.50) | PLGPLATLMNACYP2D6TDP1 | |
| SCHEMBL680677 | 0.91 | PLG (0.50) | PLGPLATLMNACYP2D6TDP1 | |
| SCHEMBL14013458 | 0.89 | CYP2D6 (0.56) | PLGPLATLMNACYP2D6TDP1 | |
| SCHEMBL10147958 | 0.89 | CYP2D6 (0.56) | PLGPLATLMNACYP2D6TDP1 | |
| SCHEMBL9408497 | 0.85 | PLG (0.69) | PLGPLATLMNACYP2D6TDP1 | |
| SCHEMBL29183505 | 0.85 | PLG (0.69) | PLGPLATLMNACYP2D6TDP1 | |
| Tranexamic Acid SCHEMBL29255943 | 0.84 | PLG (0.87) | PLGPLATLMNACYP2D6KMT2A | |
| Hydrochloric Acid SCHEMBL9408495 | 0.83 | PLG (0.67) | PLGPLATLMNACYP2D6TDP1 | |
| Tranexamic Acid SCHEMBL2184714 | 0.82 | PLG (0.91) | PLGPLATLMNACYP2D6KMT2A | |
| Tranexamic Acid SCHEMBL186034 | 0.82 | PLG (1.00) | PLGPLATLMNACYP2D6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2383253-A1 | METHOD FOR MANUFACTURING TRANS-{4-Ý(ALKYL AMINO) METHYL¨CYCLOHEXYL} ACETIC ESTER | Kowa Company, Ltd. (JP) | 2011-11-02 | — | — | EP | disclosed |