Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | CCKBR | P32239 | 9/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10149305 | 0.89 | OPRK1 (0.53) | OPRK1LMNAPDE3APDE4DCHRM2 | |
| SCHEMBL14007848 | 0.87 | OPRK1 (0.47) | OPRK1LMNAPDE3APDE4DCHRM2 | |
| SCHEMBL10149301 | 0.87 | OPRK1 (0.56) | OPRK1LMNAPDE3APDE4DCHRM2 | |
| SCHEMBL10149907 | 0.87 | OPRK1 (0.60) | OPRK1LMNAPDE3APDE4DCHRM2 | |
| SCHEMBL10165779 | 0.86 | OPRK1 (0.53) | OPRK1LMNAPDE3APDE4DCHRM2 | |
| SCHEMBL3233523 | 0.86 | OPRK1 (0.52) | OPRK1LMNAPDE3APDE4DCHRM2 | |
| SCHEMBL608039 | 0.86 | OPRK1 (0.56) | OPRK1LMNAPDE3APDE4DCHRM2 | |
| SCHEMBL14707955 | 0.86 | OPRK1 (0.56) | OPRK1LMNAPDE3APDE4DCHRM2 | |
| SCHEMBL11964629 | 0.85 | OPRK1 (0.57) | OPRK1LMNAPDE3APDE4DCHRM2 | |
| SCHEMBL2264923 | 0.85 | OPRK1 (0.57) | OPRK1LMNAPDE3APDE4DCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2422788-A2 | Benzodiazepines and compositions and uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-02-29 | — | — | EP | disclosed |