OPRK1

Kappa-type opioid receptor · P41145 · OPRK1 on Sugi Atlas →

565,747 patent compounds predicted against OPRK1, 345,684 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Butorphanol (SCHEMBL3749)	1.00	17/20
Buprenorphine (SCHEMBL15820)	1.00	14/20
Buprenorphine (SCHEMBL15821)	1.00	14/20
SCHEMBL24579	0.82	12/20
Nalbuphine (SCHEMBL3766)	1.00	10/20
Etorphine (SCHEMBL20507)	1.00	10/20
Nicomorphine (SCHEMBL26237)	0.60	10/20
Myrophine (SCHEMBL26043)	0.56	10/20
Dihydrocodeine (SCHEMBL24607)	0.74	9/20
Hydrocodone (SCHEMBL2987)	1.00	8/20
Medazepam (SCHEMBL18472)	1.00	8/20
Thebacon (SCHEMBL25766)	0.63	8/20
Trifluoroacetic Acid (SCHEMBL25141)	0.44	8/20
Morphine (SCHEMBL2997)	1.00	7/20
Metazocine (SCHEMBL26347)	1.00	7/20
Desomorphine (SCHEMBL24969)	0.67	7/20
Norlevorphanol (SCHEMBL23822)	0.56	7/20
Norlevorphanol (SCHEMBL23823)	0.56	7/20
Eptazocine (SCHEMBL25862)	0.48	7/20
Oxycodone (SCHEMBL2737)	1.00	6/20

Clinical trials — most relevant to OPRK1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Colonic Motor Patterns in Healthy Volunteers	PHASE4	COMPLETED
Oliceridine in Patients With Acute Burn Injuries	PHASE4	COMPLETED
Morphine vs. Oxycodone for Postoperative Pain Management	PHASE4	COMPLETED
Anrikefon-based Patient-controlled Intravenous Analgesia Following Laparoscopic Surgery	PHASE4	RECRUITING
Interaction Between Nalbuphine and Morphine in PCA	PHASE4	UNKNOWN
the Efficacy and Safety of Oliceridine Fumarate Injection for Acute Pain After Abdominal Surgery	PHASE4	NOT_YET_RECRUITING
Effects of Tapentadol Versus Oxycodone After Hysterectomy.	PHASE4	COMPLETED
Multimodal Versus Opioid aNalgesia in carDiAc Surgery	PHASE4	COMPLETED
Prospective Study About Clinical and Pharmacogenetic Safety of Opioid Use for Chronic Pain	PHASE4	SUSPENDED
Targeted Naltrexone for Problem Drinkers	PHASE4	COMPLETED
Effect of Buprenorphine/Naloxone Continuation on Pain Control and Opioid Use	PHASE4	UNKNOWN
Real World Study of Oxycodone/Naloxone Sustained-Release Tablets (Mimeixin) for Patients With Severe Cancer Pain	PHASE4	NOT_YET_RECRUITING
Postoperative Pain After Orthopedic Surgery: Does it Help to Give Fentanyl Before Start of Remifentanil Based Anesthesia?	PHASE3	COMPLETED
Genetic Effects on Dopamine Response to an Opiate	PHASE2	COMPLETED
Effect of Locally Administered Morphine and Bupivicaine on Acute and Chronic Postmastectomy Pain	PHASE2	COMPLETED
Sublingual Dexmedetomidine for Treating Opioid Withdrawal	PHASE1/PHASE2	ACTIVE_NOT_RECRUITING
A118G SNP and OPRM1 Gene Opioid-Mediated Effects in Humans	PHASE2	COMPLETED
The Analgesic Efficacy of Perineural Nalbuphine as an Adjuvant to Bupivacaine in Ultrasound Guided Superficial Cervical Plexus Nerve Block for Thyroid Surgeries. A Double Blinded Randomized Controlled Trial.	PHASE2	RECRUITING
Efficacy of Fentanyl Soaked Nasal Packs on Postoperative Pain in Nasal Surgeries.	PHASE2	NOT_YET_RECRUITING
Acute and Short-term Effects of Cannabidiol Admin on Cue-induced Craving in Drug-abstinent Heroin Dependent Humans	PHASE2	COMPLETED
Patient Controlled Analgesia Pharmacogenetic Study	nan	COMPLETED
Multicenter Perioperative Opioid Pharmacogenetic Study	nan	COMPLETED
Analgesia Effects of Nalbuphine vs Sulfentanil	nan	UNKNOWN
OPRM1 A118G SNP, Alcohol Response, and Striatal Dopamine	nan	COMPLETED
Determining Genetic Biomarkers Predictive of the Development of Prescription Opioid Addiction	nan	UNKNOWN
Pharmacogenetic Morphine Spine Study	nan	COMPLETED
Nalbuphine Versus Fentanyl As Additives To Bupivacaine In Spinal Anaesthesia For Internal FixationI Of Tibia	nan	COMPLETED
Effect of Intraperitoneal Bupivacaine with Dexmedotomidine or Fentanyl for Post-Operative Analgesia Following Laparoscopy in Pediatric Patients	nan	NOT_YET_RECRUITING
Effect of Preventive Analgesia with Oxycodone and Parecoxib Sodium on the Chronification of Acute Post-operative Pain	nan	NOT_YET_RECRUITING
The Effect of Oxycodone Hydrochloride on CRBD After TURBT Under General Anesthesia	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a OPRK1 binder may also engage these)

Protein	Name	Similarity
P33534	—	0.997	P33534 →
P34975	—	0.997	P34975 →
P41144	—	0.995	P41144 →
P42866	—	0.992	P42866 →
Q95M54	—	0.992	Q95M54 →
OPRM1	Mu-type opioid receptor	0.992	landscape →
Q2KIP6	—	0.991	Q2KIP6 →
Q95247	—	0.991	Q95247 →
Q5IS39	—	0.989	Q5IS39 →
P33535	—	0.989	P33535 →
P79350	—	0.987	P79350 →
Q5IS84	—	0.987	Q5IS84 →
P35377	—	0.985	P35377 →
Q9MYW9	—	0.984	Q9MYW9 →
P35370	—	0.975	P35370 →
P79292	—	0.974	P79292 →
P33533	—	0.972	P33533 →
P32300	—	0.972	P32300 →
OPRL1	Nociceptin receptor	0.967	landscape →
P47748	—	0.966	P47748 →
P30680	—	0.966	P30680 →
OPRD1	Delta-type opioid receptor	0.966	landscape →
P30875	—	0.961	P30875 →
Q49LX6	—	0.959	Q49LX6 →
P34994	—	0.957	P34994 →
SSTR2	Somatostatin receptor type 2	0.956	landscape →
Q49LX5	—	0.955	Q49LX5 →
P34993	—	0.954	P34993 →
SSTR1	Somatostatin receptor type 1	0.953	landscape →
NMBR	Neuromedin-B receptor	0.953	landscape →