Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 7/20 | 0.50 |
| ▸ | CCND1 | P24385 | 7/20 | 0.50 |
| ▸ | PRKACA | P17612 | 3/20 | 0.49 |
| ▸ | PRKACG | P22612 | 3/20 | 0.49 |
| ▸ | PRKACB | P22694 | 3/20 | 0.49 |
| ▸ | PRKCB | P05771 | 3/20 | 0.43 |
| ▸ | PRKCA | P17252 | 3/20 | 0.43 |
| ▸ | PRKCH | P24723 | 3/20 | 0.43 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.43 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.43 |
| ▸ | OPA1 | O60313 | 1/20 | 0.43 |
| ▸ | EIF5B | O60841 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.43 |
| ▸ | IDH1 | O75874 | 1/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9949540 | 0.88 | CDK4 (0.49) | CDK4CCND1PRKACAPRKACGPRKACB | |
| SCHEMBL6327449 | 0.86 | CDK4 (0.59) | CDK4CCND1PRKACAPRKACGPRKACB | |
| SCHEMBL6332262 | 0.82 | CDK4 (0.68) | CDK4CCND1PRKACAPRKACGPRKACB | |
| SCHEMBL6326531 | 0.82 | CDK4 (0.56) | CDK4CCND1PRKACAPRKACGPRKACB | |
| SCHEMBL6327465 | 0.82 | CDK4 (0.56) | CDK4CCND1PRKACAPRKACGPRKACB | |
| SCHEMBL224940 | 0.82 | CDK4 (0.61) | CDK4CCND1PRKACAPRKACGPRKACB | |
| SCHEMBL6327674 | 0.81 | CDK4 (0.50) | CDK4CCND1PRKACAPRKACGPRKACB | |
| SCHEMBL6328457 | 0.80 | CDK4 (0.46) | CDK4CCND1PRKACAPRKACGPRKACB | |
| SCHEMBL6329443 | 0.80 | CDK4 (0.51) | CDK4CCND1PRKACAPRKACGPRKACB | |
| SCHEMBL6329215 | 0.80 | CDK4 (0.53) | CDK4CCND1PRKACAPRKACGPRKACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655372-B1 | PYRROLOQUINOLINYL-PYRROLIDINE-2,5-DIONE COMPOSITIONS AND METHODS FOR PREPARING AND USING SAME | ARQULE INC (US) | 2016-03-16 | — | — | EP | disclosed |
| US-8470786-B2 | Pyrroloquinolinyl-pyrrolidine-2,5-dione compositions and methods for preparing and using same | ARQULE, INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-20120165278-A1 | Pyrroloquinolinyl-Pyrrolidine-2,5-Dione Compositions And Methods For Preparing And Using Same | ARQULE, INC. (US) | 2012-06-28 | — | — | US | disclosed |
| WO-2012088491-A2 | PYRROLOQUINOLINYL-PYRROLIDINE-2,5-DIONE COMPOSITIONS AND METHODS FOR PREPARING AND USING SAME | ARQULE, INC. (US) | 2012-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165278-A1 | Pyrroloquinolinyl-Pyrrolidine-2,5-Dione Compositions And Methods For Preparing And Using Same | DHPS, PDCD5, DPYD | CDK4 79/4885CCND1 164/4885PRKACA 1854/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.