Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.52 |
| ▸ | STAT6 | P42226 | 5/20 | 0.38 |
| ▸ | SMAD3 | P84022 | 5/20 | 0.38 |
| ▸ | SMAD2 | Q15796 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.38 |
| ▸ | CBR1 | P16152 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10150085 | 0.90 | HSP90AB1 (0.48) | HSP90AB1STAT6SMAD3SMAD2MAPT | |
| SCHEMBL10150022 | 0.88 | HSP90AB1 (0.47) | HSP90AB1STAT6SMAD3SMAD2MAPT | |
| SCHEMBL10150021 | 0.81 | HSP90AB1 (0.70) | HSP90AB1STAT6SMAD3SMAD2MAPT | |
| SCHEMBL10150018 | 0.81 | HSP90AB1 (0.70) | HSP90AB1STAT6SMAD3SMAD2MAPT | |
| SCHEMBL19418251 | 0.80 | HSP90AB1 (0.57) | HSP90AB1STAT6SMAD3SMAD2MAPT | |
| SCHEMBL19418258 | 0.79 | HSP90AB1 (0.44) | HSP90AB1STAT6SMAD3SMAD2MAPT | |
| SCHEMBL19418043 | 0.78 | HSP90AB1 (0.42) | HSP90AB1MAPTMEN1KMT2AGAA | |
| SCHEMBL10150079 | 0.77 | HSP90AB1 (0.67) | HSP90AB1STAT6SMAD3SMAD2MAPT | |
| SCHEMBL13049717 | 0.77 | HSP90AB1 (0.52) | HSP90AB1STAT6SMAD3SMAD2MAPT | |
| SCHEMBL12142596 | 0.75 | HSP90AB1 (0.64) | HSP90AB1STAT6SMAD3SMAD2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450305-B2 | Macrocyclic compounds useful as inhibitors of kinases and HSP90 | UNIVERSITE DE STRASBOURG (FR) | 2013-05-28 | — | — | US | disclosed |
| US-20120077775-A1 | MACROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF KINASES AND HSP90 | LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077775-A1 | MACROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF KINASES AND HSP90 | HSP90AB1, HSP90AA1, HSP90AB2P | HSP90AB1 1/4885STAT6 3150/4885SMAD3 811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.