SCHEMBL19418043

SCHEMBL19418043

COC1CC/C=C/C[C@H](c2ccccc2)OC(=O)c2c(O)cc(O)c(Cl)c2CC(O)C1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AB1 P08238 3/20 0.42
ABCG2 Q9UNQ0 1/20 0.39
CYP3A4 P08684 2/20 0.36
CYP2D6 P10635 2/20 0.36
CYP2C9 P11712 2/20 0.36
CYP2C19 P33261 2/20 0.36
ACHE P22303 1/20 0.36
CYP19A1 P11511 2/20 0.36
MEN1 O00255 2/20 0.35
MAPT P10636 2/20 0.35
KMT2A Q03164 2/20 0.35
CYP1A1 P04798 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP1B1 Q16678 1/20 0.35
HSD17B10 Q99714 1/20 0.35
CDK4 P11802 4/20 0.35
CCND1 P24385 4/20 0.35
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
POLB P06746 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10150022 0.87 HSP90AB1 (0.47) HSP90AB1ABCG2CYP3A4CYP2D6CYP2C9
SCHEMBL10150690 0.78 HSP90AB1 (0.52) HSP90AB1ABCG2CYP3A4CYP2D6CYP2C9
SCHEMBL10150085 0.77 HSP90AB1 (0.48) HSP90AB1ABCG2CYP3A4CYP2D6CYP2C9
SCHEMBL19418258 0.76 HSP90AB1 (0.44) HSP90AB1ABCG2CYP3A4CYP2D6CYP2C9
SCHEMBL10150021 0.75 HSP90AB1 (0.70) HSP90AB1CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL10150018 0.75 HSP90AB1 (0.70) HSP90AB1CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL13049717 0.74 HSP90AB1 (0.52) HSP90AB1ABCG2CYP19A1MEN1MAPT
SCHEMBL19418251 0.73 HSP90AB1 (0.57) HSP90AB1CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL19417971 0.73 HSP90AB1 (0.45) HSP90AB1ABCG2CYP3A4CYP2D6CYP2C9
SCHEMBL19418317 0.70 HSP90AB1 (0.56) HSP90AB1CYP3A4CYP2D6CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2136799-B1 MACROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF KINASES AND HSP90 UNIV STRASBOURG (FR) 2017-10-04 EP disclosed