Sugi Predict

Sugi Predict / Compounds / SCHEMBL10151101

SCHEMBL10151101

SCHEMBL10151101

Cc1ccc(COC(C)C)s1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PRMT6 Q96LA8 1/20 0.45
▸ THRB P10828 2/20 0.38
▸ TP53 P04637 1/20 0.38
▸ ADRA1D P25100 2/20 0.36
▸ ALDH1A1 P00352 3/20 0.35
▸ KMT2A Q03164 3/20 0.35
▸ KDM4E B2RXH2 2/20 0.35
▸ MEN1 O00255 2/20 0.35
▸ GAA P10253 1/20 0.35
▸ MAPT P10636 1/20 0.35
▸ HPGD P15428 1/20 0.35
▸ HSD17B10 Q99714 1/20 0.35
▸ RIPK1 Q13546 1/20 0.33
▸ CYP3A4 P08684 2/20 0.32
▸ CYP2D6 P10635 2/20 0.32
▸ SLC6A2 P23975 2/20 0.32
▸ SLC6A4 P31645 2/20 0.32
▸ SLC6A3 Q01959 2/20 0.32
▸ KCNH2 Q12809 2/20 0.32
▸ RAB9A P51151 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18742099 0.78 — —
SCHEMBL12461696 0.76 — —
SCHEMBL22733817 0.72 PRMT6 (0.47) PRMT6THRBTP53ADRA1DALDH1A1
SCHEMBL13218002 0.72 PRMT6 (0.47) PRMT6THRBTP53ADRA1DALDH1A1
SCHEMBL12508125 0.72 DPP4 (0.50) PRMT6THRBTP53ADRA1DALDH1A1
SCHEMBL6844118 0.71 PRMT6 (0.50) PRMT6THRBTP53ADRA1DALDH1A1
SCHEMBL18720620 0.71 MAPT (0.47) ALDH1A1KMT2AKDM4EMEN1GAA
SCHEMBL8655718 0.69 PRMT6 (0.40) PRMT6THRBTP53ADRA1DALDH1A1
SCHEMBL19051432 0.69 PRMT6 (0.44) PRMT6THRBTP53ADRA1DALDH1A1
SCHEMBL14049755 0.69 PRMT6 (0.44) PRMT6THRBTP53ADRA1DALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021139482-A1 CARBOXYLIC ACID DERIVATIVE-SUBSTITUTED IMINO ARYL COMPOUND, PREPARATION METHOD THEREFOR, HERBICIDAL COMPOSITION AND USE THEREOF 青岛清原化合物有限公司 2021-07-15 — — WO disclosed
US-20120076756-A1 NOVEL BENZIMIDAZOLE DERIVATIVES ENANTA PHARMACEUTICALS, INC. 2012-03-29 — — US disclosed
US-8101643-B2 Benzimidazole derivatives ENANTA PHARMACEUTICALS, INC. (US) 2012-01-24 — — US disclosed
US-20100260715-A1 HEPATITIS C VIRUS INHIBITORS ENANTA PHARMACEUTICALS, INC. 2010-10-14 — — US disclosed
US-20100233122-A1 NOVEL BENZIMIDAZOLE DERIVATIVES ENANTA PHARMACEUTICALS, INC. 2010-09-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120076756-A1 NOVEL BENZIMIDAZOLE DERIVATIVES EIF2AK2, ZC3HAV1, HAVCR2 PRMT6 2099/4885THRB 4333/4885TP53 1313/4885
US-20100260715-A1 HEPATITIS C VIRUS INHIBITORS HAVCR2, SLC10A1, EIF2AK2 PRMT6 1808/4885THRB 4251/4885TP53 1162/4885
US-20100233122-A1 NOVEL BENZIMIDAZOLE DERIVATIVES EIF2AK2, ZC3HAV1, HAVCR2 PRMT6 2099/4885THRB 4333/4885TP53 1313/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.