PRMT6 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL39876	0.58	16/20
SCHEMBL39855	0.54	12/20
SCHEMBL381729	0.64	8/20
Lithium Ion (SCHEMBL381730)	0.63	8/20
SCHEMBL159689	0.53	8/20
SCHEMBL77007	0.95	6/20
SCHEMBL250253	0.73	6/20
SCHEMBL606815	0.52	6/20
SCHEMBL604129	0.43	6/20
SCHEMBL320058	0.47	4/20
SCHEMBL610219	0.41	4/20
SCHEMBL543919	1.00	3/20
SCHEMBL95597	0.71	3/20
SCHEMBL360084	0.71	3/20
SCHEMBL153896	0.67	3/20
SCHEMBL349032	0.65	3/20
SCHEMBL327856	0.64	3/20
SCHEMBL527268	0.58	3/20
SCHEMBL297864	0.53	3/20
SCHEMBL374836	0.51	3/20

Clinical trials — most relevant to PRMT6 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
L-arginine Treatment in Mild Hypertension	PHASE4	UNKNOWN
A Phase 1/2/3 Study of TSHA-102 Gene Therapy in Females With Rett Syndrome (REVEAL Pivotal Study)	PHASE3	RECRUITING
Safety and Efficacy of BMS-986504 in Unresectable Malignant Peripheral Nerve Sheath Tumor	PHASE1/PHASE2	NOT_YET_RECRUITING
A Study of PRMT5 Inhibitor BAY 3713372 in Participants With MTAP-deleted Solid Tumors	PHASE1/PHASE2	RECRUITING
Treatment With Azacitidine of Recurrent Gliomas With IDH1/2 Mutation	PHASE2	UNKNOWN
Decitabine/Cedazuridine (INQOVI), an Oral DNA Demethylating Agent, in Subjects With BAP1 Cancer Predisposition Syndrome and Subclinical, Early-Stage Mesothelioma	PHASE2	SUSPENDED
Effect of Arginine- and Glutamine-based Oral Formulations on Salivary Biomarkers and Clinical Severity of Radiation-induced Oral Mucositis in Head and Neck Cancer: A Randomized Controlled Trial	PHASE2	COMPLETED
Nitrite Supplementation in Long COVID Patients	PHASE2	COMPLETED
An Investigational Study of BGB-58067 As a Single Agent and in Combination With Anticancer Agents in Participants With Advanced Solid Tumors	PHASE1	RECRUITING
Oral Decitabine (ASTX727) and Durvalumab in Recurrent and/or Metastatic Head and Neck Cancer Patients	PHASE1	COMPLETED
Novel Molecular Targets and Innovative Therapeutic Perspective in Medulloblastoma	EARLY_PHASE1	RECRUITING
Single-Dose AAV-MECP2 Safety/Tolerability and Efficacy in Rett Syndrome	EARLY_PHASE1	ACTIVE_NOT_RECRUITING
Investigation of Methylation of EGFR in the Response of the Cetuximab in Metastatic Colorectal Cancer Patients	nan	COMPLETED
The Clinical Value of the Nitric Oxide System Components in Asthma and COPD	nan	UNKNOWN
The Correlation Between Serum PRMT5 Level and Cardiac Ultrasound Indicators in Patients With Heart Failure	nan	ENROLLING_BY_INVITATION
Patient's Derived Organoids for Drug Screening in Glioblastoma	nan	NOT_YET_RECRUITING
The Molecular Pathogenesis Study of Cataract	nan	UNKNOWN
Studying The Role of Key Epigenetic Mediators in Breast Cancer Patients	nan	RECRUITING
Epitranscriptomic Blood Biomarkers for Coronary Artery Disease - A Prospective Cohort Study (IHD-EPITRAN)	nan	UNKNOWN
Nitric Oxide Supplementation on Neurocognitive Functions in Patients With ASLD	nan	COMPLETED
Markers of Cardiovascular Risk in Patients With Premature Coronary Artery Disease and Treatment	nan	UNKNOWN
DNA Methylation and Perioperative Pain Treatment	nan	COMPLETED
Study of the Articular Microbiota in Rheumatoid Arthritis.	nan	COMPLETED
Biocollection in MyeloDysplastic Syndrome (P-MDS)	nan	RECRUITING
Impact of Weight Loss on the Human Sperm Epitranscriptome	nan	ACTIVE_NOT_RECRUITING
Target of Suv420h1/2 in Hepatocytes	nan	RECRUITING
Mechanisms of Immune Deficiency	nan	UNKNOWN
Effects of Contact Restrictions During the COVID-19 Pandemic on Newborns and Their Parents	nan	COMPLETED
Methylation of DNA in Children and Adolescents With Type 1 Diabetes Mellitus (METHYLDIAB)	nan	COMPLETED
Preterm Arginine INTake Study	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a PRMT6 binder may also engage these)

Protein	Name	Similarity
Q5E9L5	—	1.000	Q5E9L5 →
Q6NZB1	—	0.999	Q6NZB1 →
Q7QIL2	—	0.991	Q7QIL2 →
B4P925	—	0.990	B4P925 →
Q6ZSI9	—	0.988	Q6ZSI9 →
Q2QMG2	—	0.987	Q2QMG2 →
Q9MAT5	—	0.986	Q9MAT5 →
A2Y953	—	0.986	A2Y953 →
Q5ZHX9	—	0.986	Q5ZHX9 →
B4I8G2	—	0.985	B4I8G2 →
Q9W1V1	—	0.985	Q9W1V1 →
B4QI55	—	0.984	B4QI55 →
Q5MNI5	—	0.984	Q5MNI5 →
Q4Q089	—	0.984	Q4Q089 →
Q26228	—	0.984	Q26228 →
B0JYW5	—	0.984	B0JYW5 →
Q582G4	—	0.984	Q582G4 →
Q68EZ3	—	0.983	Q68EZ3 →
Q5RCH4	—	0.983	Q5RCH4 →
SMOX	Spermine oxidase	0.983	landscape →
Q8S6N5	—	0.982	Q8S6N5 →
Q9SNQ2	—	0.982	Q9SNQ2 →
Q3TRM8	—	0.982	Q3TRM8 →
P28855	—	0.982	P28855 →
Q8WYJ6	—	0.982	Q8WYJ6 →
Q28DX0	—	0.982	Q28DX0 →
F7EZ75	—	0.982	F7EZ75 →
Q8LI34	—	0.981	Q8LI34 →
Q1HVC1	—	0.981	Q1HVC1 →
Q9ER56	—	0.981	Q9ER56 →