SCHEMBL10151692

SCHEMBL10151692

O=C(NC[C@H]1CN(c2ccc(N3CCNN(C(=O)Cn4cnnn4)CC3)c(F)c2)C(=O)O1)C(F)F

nearest known ligand 0.49

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
F10 P00742 11/20 0.49
MAOB P27338 8/20 0.49
MAOA P21397 5/20 0.49
LMNA P02545 1/20 0.49
PTGS1 P23219 1/20 0.49
CALML3 P27482 1/20 0.49
SDHA P31040 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10151691 0.91 MAOB (0.61) F10MAOBMAOALMNAPTGS1
SCHEMBL10151687 0.90 MAOB (0.54) F10MAOBMAOALMNAPTGS1
SCHEMBL10151554 0.87 F10 (0.57) F10MAOBMAOALMNAPTGS1
SCHEMBL10152284 0.87 MAOB (0.53) F10MAOBMAOALMNAPTGS1
SCHEMBL10151690 0.87 F10 (0.49) F10MAOBMAOALMNAPTGS1
SCHEMBL10151667 0.85 MAOB (0.53) F10MAOBMAOALMNAPTGS1
SCHEMBL13367939 0.85 F10 (0.55) F10MAOBMAOALMNAPTGS1
SCHEMBL15827718 0.85 F10 (0.50) F10MAOBMAOALMNAPTGS1
SCHEMBL10151680 0.85 MAOB (0.53) F10MAOBMAOALMNAPTGS1
SCHEMBL10151662 0.84 MAOB (0.56) F10MAOBMAOALMNAPTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2009012-B1 NOVEL COMPOUND HAVING HETEROCYCLIC RING RES FOUND ITSUU LAB (JP) 2014-06-25 EP disclosed
US-8148362-B2 Compound having heterocyclic ring RESEARCH FOUNDATION ITSUU LABORATORY (JP) 2012-04-03 US disclosed
EP-2181994-A1 Antimicrobial compounds Research Foundation Itsuu Laboratory (JP) 2010-05-05 EP disclosed
EP-2181993-A1 Antimicrobial oxazolidinone derivatives Research Foundation Itsuu Laboratory (JP) 2010-05-05 EP disclosed
US-20090299059-A1 Novel Compound Having Heterocyclic Ring RESEARCH FOUNDATION ITSUU LABORATORY (JP) 2009-12-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090299059-A1 Novel Compound Having Heterocyclic Ring NR0B2, NR2C2, NR0B1 F10 3469/4885MAOB 2611/4885MAOA 2965/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.