Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 11/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31653994 | 1.00 | KCNA5 (0.48) | KCNA5KCNH2HDAC3HDAC4HDAC7 | |
| SCHEMBL19380274 | 0.84 | HDAC4 (0.44) | KCNA5KCNH2HDAC3HDAC4HDAC7 | |
| SCHEMBL9958705 | 0.82 | HDAC4 (0.62) | HDAC3HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL10153609 | 0.82 | MEN1 (0.47) | HDAC3HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL31653962 | 0.82 | MEN1 (0.47) | HDAC3HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL10154010 | 0.81 | MAPT (0.44) | KCNA5HDAC3HDAC4HDAC7HDAC8 | |
| SCHEMBL22461359 | 0.80 | HDAC4 (0.61) | KCNA5KCNH2HDAC3HDAC4HDAC7 | |
| SCHEMBL10153604 | 0.78 | KCNA5 (0.47) | KCNA5KCNH2HDAC3HDAC4HDAC7 | |
| SCHEMBL19380301 | 0.78 | HDAC3 (0.40) | HDAC3HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL9958675 | 0.77 | KMT2A (0.50) | KCNA5KCNH2MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085003-A1 | 2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONES AND RELATED COMPOUNDS USEFUL AS HIV REPLICATION INHIBITORS | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-06-28 | — | — | WO | disclosed |