Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | STS | P08842 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1245452 | 0.84 | HPGD (0.62) | SMN1; SMN2NPC1RAB9APTPN2PTPN1 | |
| SCHEMBL5271075 | 0.80 | SMN1; SMN2 (0.62) | SMN1; SMN2ALDH1A1NPC1RAB9AGAA | |
| SCHEMBL12436920 | 0.80 | GAA (0.46) | SMN1; SMN2ALDH1A1NPC1RAB9AGAA | |
| SCHEMBL3498368 | 0.80 | LMNA (0.55) | SMN1; SMN2NPC1RAB9AGAAKMT2A | |
| SCHEMBL1034955 | 0.80 | SMN1; SMN2 (0.54) | SMN1; SMN2ALDH1A1GAAKMT2AMEN1 | |
| SCHEMBL8351549 | 0.80 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1KMT2AMEN1EPHX1 | |
| SCHEMBL20993453 | 0.79 | EPHX1 (0.45) | SMN1; SMN2GAAHPGDEPHX1MAPT | |
| SCHEMBL18330356 | 0.79 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1GAAPTPN1KMT2A | |
| SCHEMBL13627837 | 0.79 | HSD17B10 (0.46) | SMN1; SMN2ALDH1A1NPC1RAB9AGAA | |
| SCHEMBL13627846 | 0.79 | HSD17B10 (0.46) | SMN1; SMN2ALDH1A1NPC1RAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165309-A1 | HETERO RING DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-06-28 | — | — | US | disclosed |
| EP-2397479-A1 | HETERO RING DERIVATIVE | Astellas Pharma Inc. (JP) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010092962-A1 | HETERO RING DERIVATIVE | アステラス製薬株式会社 (JP) | 2010-08-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165309-A1 | HETERO RING DERIVATIVE | IL2, PIK3R2, IL2RA | SMN1; SMN2 4237/4885ALDH1A1 3496/4885NPC1 4598/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.