Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.53 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.52 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12328884 | 1.00 | DPP4 (0.53) | DPP4ERAP2LNPEPMAPTNPC1 | |
| SCHEMBL12326257 | 0.95 | SLC2A1 (0.52) | DPP4ERAP2LNPEPMAPTNPC1 | |
| SCHEMBL14551497 | 0.95 | SLC2A1 (0.52) | DPP4ERAP2LNPEPMAPTNPC1 | |
| SCHEMBL20874440 | 0.91 | DPP4 (0.49) | DPP4ERAP2LNPEPMAPTNPC1 | |
| SCHEMBL12326223 | 0.90 | DPP4 (0.56) | DPP4ERAP2LNPEPMAPTNPC1 | |
| SCHEMBL14550338 | 0.90 | DPP4 (0.56) | DPP4ERAP2LNPEPMAPTNPC1 | |
| SCHEMBL14550548 | 0.85 | CA12 (0.50) | DPP4ERAP2LNPEPMAPTNPC1 | |
| SCHEMBL14551239 | 0.84 | DPP4 (0.56) | DPP4MAPTNPC1RAB9ALOXL2 | |
| SCHEMBL12326121 | 0.84 | DPP4 (0.56) | DPP4MAPTNPC1RAB9ALOXL2 | |
| SCHEMBL1765662 | 0.84 | NPC1 (0.50) | ERAP2LNPEPMAPTNPC1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012009226-A1 | SUBSTITUTED IMIDAZOLONES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK SHARP & DOHME CORP. (US) | 2012-01-19 | — | — | WO | disclosed |
| WO-2011119559-A1 | NOVEL SPIRO IMIDAZOLONES AS GLUCAGON RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS FOR THEIR USE | SCHERING CORPORATION (US) | 2011-09-29 | — | — | WO | disclosed |