Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 15/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1015450 | 1.00 | HTR6 (0.40) | HTR6CHRM2CHRM1 | |
| SCHEMBL13210846 | 1.00 | HTR6 (0.40) | HTR6CHRM2CHRM1 | |
| SCHEMBL1015449 | 1.00 | HTR6 (0.40) | HTR6CHRM2CHRM1 | |
| SCHEMBL1015810 | 0.87 | HTR6 (0.45) | HTR6CHRM2CHRM1 | |
| SCHEMBL1015809 | 0.87 | HTR6 (0.45) | HTR6CHRM2CHRM1 | |
| SCHEMBL1014775 | 0.85 | HTR6 (0.45) | HTR6 | |
| SCHEMBL1015899 | 0.85 | HTR6 (0.45) | HTR6 | |
| SCHEMBL1015647 | 0.78 | HTR6 (0.50) | HTR6CHRM2CHRM1 | |
| SCHEMBL1015648 | 0.78 | HTR6 (0.50) | HTR6CHRM2CHRM1 | |
| SCHEMBL1015649 | 0.78 | HTR6 (0.50) | HTR6CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081890-B1 | ARYLSULFONYL PYRROLIDINES AS 5-HT6 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-01-12 | — | — | EP | claimed |
| EP-2081890-A1 | ARYLSULFONYL PYRROLIDINES AS 5-HT6 INHIBITORS | F. Hoffmann-Roche AG (CH) | 2009-07-29 | — | — | EP | claimed |
| WO-2008055847-A1 | ARYLSULFONYL PYRROLIDINES AS 5-HT6 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-15 | — | — | WO | claimed |
| EP-2081890-B1 | ARYLSULFONYL PYRROLIDINES AS 5-HT6 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-01-12 | — | — | EP | disclosed |
| US-7776910-B2 | Arylsulfonyl pyrrolidines as 5-HT6 inhibitors | ROCHE PALO ALTO LLC (US) | 2010-08-17 | — | — | US | disclosed |