Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.58 |
| ▸ | NNMT | P40261 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.37 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.37 |
| ▸ | MIF | P14174 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ASPH | Q12797 | 1/20 | 0.34 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL347508 | 0.86 | SIRT6 (0.75) | SIRT6NNMTKDM4EMAPK1L3MBTL1 | |
| SCHEMBL31132573 | 0.86 | SIRT6 (0.75) | SIRT6NNMTKDM4EMAPK1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL17668902 | 0.85 | SIRT6 (0.72) | SIRT6NNMTKDM4EMAPK1L3MBTL1 | |
| SCHEMBL17727927 | 0.84 | SIRT6 (0.51) | SIRT6NNMTKDM4EMAPK1L3MBTL1 | |
| Hydrazine SCHEMBL28698640 | 0.83 | SIRT6 (0.76) | SIRT6NNMTKDM4EMAPK1L3MBTL1 | |
| SCHEMBL17736459 | 0.79 | SIRT6 (0.59) | SIRT6NNMTKDM4EMAPK1L3MBTL1 | |
| SCHEMBL991588 | 0.76 | MAPT (0.56) | SIRT6KDM4EMAPK1L3MBTL1HCAR2 | |
| SCHEMBL70035 | 0.74 | KDM4E (0.59) | SIRT6KDM4EMAPK1L3MBTL1HCAR2 | |
| SCHEMBL9947622 | 0.74 | SIRT6 (0.49) | SIRT6KDM4EMAPK1L3MBTL1HCAR2 | |
| SCHEMBL13524601 | 0.73 | SIRT6 (0.67) | SIRT6NNMTKDM4EMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3218362-B1 | 2-AMINO-3,5-DIFLUORO-3,6-DIMETHYL-6-PHENYL-3,4,5,6-TETRAHYDROPYRIDINES AS BACE1 INHIBITORS FOR TREATING ALZHEIMER'S DISEASE | H LUNDBECK AS (DK) | 2019-01-09 | — | — | EP | disclosed |
| US-10059669-B2 | 2-amino-3,5-difluoro-3,6-dimethyl-6-phenyl-3,4,5,6-tetrahydropyridines as BACE1 inhibitors for treating alzheimer's disease | H. LUNDBECK A/S (DK) | 2018-08-28 | — | — | US | disclosed |
| EP-3334738-A1 | 2-AMINO-7A-PHENYL-3,4,4A,5,7,7A-HEXAHYDROFURO[3,4-B]PYRIDINES AS BACE1 INHIBITORS | H. Lundbeck A/S (DK) | 2018-06-20 | — | — | EP | disclosed |
| US-20170313658-A1 | 2-Amino-3,5-Difluoro-3,6-Dimethyl-6-Phenyl-3,4,5,6-Tetrahydropyridines as BACE1 Inhibitors for Treating Alzheimer's Disease | H. LUNDBECK A/S (DK) | 2017-11-02 | — | — | US | disclosed |
| WO-2017025565-A1 | 2-AMINO-7A-PHENYL-3,4,4A,5,7,7A-HEXAHYDROFURO[3,4-B]PYRIDINES AS BACE1 INHIBITORS | H. LUNDBECK A/S (DK) | 2017-02-16 | — | — | WO | disclosed |
| US-20120015961-A1 | ISOTHIOUREA DERIVATIVES OR ISOUREA DERIVATIVES HAVING BACE1 INHIBITORY ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015961-A1 | ISOTHIOUREA DERIVATIVES OR ISOUREA DERIVATIVES HAVING BACE1 INHIBITORY ACTIVITY | BACE1, BACE2, APP | SIRT6 3301/4885NNMT 1986/4885KDM4E 2418/4885 |
| US-10059669-B2 | 2-amino-3,5-difluoro-3,6-dimethyl-6-phenyl-3,4,5,6-tetrahydropyridines as BACE1 inhibitors for treating alzheimer's disease | BACE1, BACE2, APP | SIRT6 1116/4885NNMT 406/4885KDM4E 613/4885 |
| US-20170313658-A1 | 2-Amino-3,5-Difluoro-3,6-Dimethyl-6-Phenyl-3,4,5,6-Tetrahydropyridines as BACE1 Inhibitors for Treating Alzheimer's Disease | BACE1, BACE2, APP | SIRT6 1116/4885NNMT 406/4885KDM4E 613/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.