SCHEMBL10156085

SCHEMBL10156085

CCN(C)c1nc(N(C)CC)nc(N(C)CC)n1

nearest known ligand 0.44

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.44
LMNA P02545 1/20 0.44
THRB P10828 1/20 0.44
BLM P54132 1/20 0.44
CREBBP Q92793 1/20 0.44
HSD17B10 Q99714 1/20 0.44
TSHR P16473 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
USP2 O75604 1/20 0.31
ALOX15 P16050 1/20 0.31
GAA P10253 1/20 0.31
CYP2C19 P33261 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
SMN1; SMN2 Q16637 2/20 0.30
MAPT P10636 1/20 0.30
KDM4E B2RXH2 1/20 0.30
ALDH1A1 P00352 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13562971 0.91 LMNA (0.61) CYP1A2LMNATHRBBLMCREBBP
SCHEMBL13562968 0.91 LMNA (0.38) CYP1A2LMNATHRBBLMCREBBP
SCHEMBL1537657 0.91 LMNA (0.61) CYP1A2LMNATHRBBLMCREBBP
SCHEMBL13531629 0.89 TSHR (0.52) CYP1A2LMNATHRBBLMCREBBP
SCHEMBL12610491 0.87 LMNA (0.35) CYP1A2LMNATHRBBLMCREBBP
SCHEMBL13562969 0.87 MAPT (0.44) CYP1A2LMNATHRBBLMCREBBP
SCHEMBL13562967 0.87 LMNA (0.35) CYP1A2LMNATHRBBLMCREBBP
SCHEMBL13562970 0.83 LMNA (0.37) CYP1A2LMNATHRBBLMCREBBP
SCHEMBL8680001 0.81 MAPT (0.40) CYP1A2LMNATSHRGAACYP2C19
SCHEMBL11221763 0.81

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8802848-B2 Melamine based mannich-compounds and a process for obtaining the same BOREALIS AGROLINZ MELAMINE GMBH (AT) 2014-08-12 US disclosed
US-20120277429-A1 Melamine Based Mannich-Compounds and a Process for Obtaining the Same BOREALIS AGROLINZ MELAMINE GMBH (AT) 2012-11-01 US disclosed
US-20120277429-A1 Melamine Based Mannich-Compounds and a Process for Obtaining the Same BOREALIS AGROLINZ MELAMINE GMBH (AT) 2012-11-01 US disclosed
US-8277695-B2 Reversibly thermochromic compositions BASF SE (DE) 2012-10-02 US disclosed
US-8119778-B2 Reversibly thermochromic compositions BASF SE (DE) 2012-02-21 US disclosed
US-20110180767-A1 Reversibly thermochromic compositions CIBA CORPORATION 2011-07-28 US disclosed
US-20110092632-A1 POROUS INORGANIC MATERIALS CONTAINING POLYMER ADDITIVES BRAND FABIEN JEAN 2011-04-21 US disclosed
US-7820744-B2 Stabilizer mixtures CIBA SPECIALTY CHEMICALS CORP. (US) 2010-10-26 US disclosed
US-20100048773-A1 AGRICULTURAL ARTICLES BONORA MICHELA 2010-02-25 US disclosed
US-20100048774-A1 STABILIZER MIXTURES GUGUMUS FRANCOIS 2010-02-25 US disclosed
US-7652081-B2 Stabilizer mixtures CIBA SPECIALTY CHEMICALS CORPORATION (US) 2010-01-26 US disclosed
US-7628936-B2 Mixture of steric hindred amine compound with magnesium and zinc salt; photostability; heat and oxidation resistance; for polymers CIBA SPECIALTY CHEMICALS CORPORATION (US) 2009-12-08 US disclosed
US-7595008-B2 Mixture containing steric hindred amine compound with zinc and magnesium salt; photostability; heat and oxidation resistance; for polymers CIBA SPECIALTY CHEMICALS CORPORATION (US) 2009-09-29 US disclosed
US-20090111917-A1 Stabilized articles BONORA MICHELA 2009-04-30 US disclosed
US-20090105379-A1 Stabilizer mixtures GUGUMUS FRANCOIS 2009-04-23 US disclosed
US-20090093572-A1 Stabilizer mixtures GUGUMUS FRANCOIS 2009-04-09 US disclosed
US-20080058459-A1 Porous Inorganic Materials Containing Polymer Additives CIBA CORP. 2008-03-06 US disclosed
US-20070135537-A1 Agricultural articles BONORA MICHAEL 2007-06-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110180767-A1 Reversibly thermochromic compositions C1R, C3AR1, C9 CYP1A2 145/4885LMNA 2222/4885THRB 217/4885
US-20120277429-A1 Melamine Based Mannich-Compounds and a Process for Obtaining the Same MAN2A1, MANBA, MAN2B2 CYP1A2 332/4885LMNA 297/4885THRB 3586/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.