SCHEMBL1015771

SCHEMBL1015771

Nc1ccc(Cl)cc1C(=O)OCc1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.55
L3MBTL1 Q9Y468 3/20 0.55
CYP3A4 P08684 2/20 0.55
CYP1A2 P05177 1/20 0.55
CYP2C9 P11712 1/20 0.55
CYP2C19 P33261 1/20 0.55
NPSR1 Q6W5P4 1/20 0.55
TDP1 Q9NUW8 3/20 0.53
POLB P06746 1/20 0.52
RAB9A P51151 3/20 0.52
RECQL P46063 1/20 0.51
KDM4E B2RXH2 2/20 0.51
NPC1 O15118 2/20 0.50
SLC6A2 P23975 1/20 0.50
SLC6A3 Q01959 1/20 0.50
KMT2A Q03164 1/20 0.50
HPGD P15428 2/20 0.49
DHODH Q02127 2/20 0.49
MAPT P10636 2/20 0.49
LMNA P02545 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4771212 0.84 ALDH1A1 (0.60) ALDH1A1L3MBTL1CYP3A4CYP1A2CYP2C9
SCHEMBL6832242 0.84 TDP1 (0.67) ALDH1A1L3MBTL1CYP3A4CYP1A2CYP2C9
SCHEMBL23812446 0.84 TDP1 (0.60) ALDH1A1L3MBTL1CYP3A4TDP1POLB
SCHEMBL8292502 0.83 ALDH1A1 (0.47) ALDH1A1L3MBTL1CYP3A4CYP1A2CYP2C9
SCHEMBL31189998 0.82 POLB (0.56) ALDH1A1L3MBTL1CYP3A4NPSR1TDP1
SCHEMBL27413685 0.82 POLB (0.56) ALDH1A1L3MBTL1CYP3A4NPSR1TDP1
SCHEMBL20831012 0.82 ALDH1A1 (0.55) ALDH1A1L3MBTL1CYP3A4CYP1A2CYP2C9
SCHEMBL2706430 0.82 NPC1 (0.63) ALDH1A1L3MBTL1CYP3A4CYP1A2CYP2C9
SCHEMBL23812467 0.81 ALDH1A1 (0.60) ALDH1A1L3MBTL1CYP3A4CYP1A2CYP2C9
SCHEMBL1649274 0.81 PTGER1 (0.62) ALDH1A1L3MBTL1CYP3A4CYP1A2CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3099687-B1 MACROCYCLES WITH HETROCYCLIC P2' GROUPS AS FACTOR XIA INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2018-07-04 EP disclosed
EP-2272822-A1 INHIBITOR OF PLASMINOGEN ACTIVATOR INHIBITOR-1 Renascience CO., LTD. (JP) 2011-01-12 EP disclosed