Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 18/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 17/20 | 0.56 |
| ▸ | KMO | O15229 | 2/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6893242 | 0.88 | PIK3CA (0.56) | MTORPIK3CA | |
| SCHEMBL10157327 | 0.88 | MTOR (0.72) | MTORPIK3CA | |
| SCHEMBL12137738 | 0.87 | MTOR (0.46) | MTORPIK3CACCNE1CDK2 | |
| SCHEMBL6894212 | 0.87 | PIK3CA (0.57) | MTORPIK3CA | |
| SCHEMBL6890802 | 0.86 | PIK3CA (0.56) | MTORPIK3CA | |
| SCHEMBL10157689 | 0.84 | MTOR (0.74) | MTORPIK3CACCNE1CDK2 | |
| SCHEMBL516932 | 0.83 | PIK3CA (0.80) | MTORPIK3CA | |
| SCHEMBL7872340 | 0.81 | MTOR (0.55) | MTORPIK3CACCNE1CDK2 | |
| SCHEMBL10157679 | 0.81 | MTOR (0.75) | MTORPIK3CACCNE1CDK2 | |
| SCHEMBL6893240 | 0.80 | GABRP (0.51) | MTORPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120028952-A1 | 5-ALKYNYL-PYRIMIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028952-A1 | 5-ALKYNYL-PYRIMIDINES | MKI67, CCNA1, CCNT1 | MTOR 1291/4885PIK3CA 1371/4885KMO 2777/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.