GABRP — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL15406	0.61	20/20
Fipronil (SCHEMBL15088)	0.59	20/20
SCHEMBL41972	0.59	20/20
Fipronil (SCHEMBL44222)	0.59	20/20
Ethiprole (SCHEMBL27048)	0.56	20/20
SCHEMBL25897	0.51	20/20
SCHEMBL33214	0.52	19/20
SCHEMBL26584	0.51	19/20
SCHEMBL9107	0.56	12/20
SCHEMBL8532	1.00	11/20
SCHEMBL9035	0.56	10/20
SCHEMBL8632	0.54	10/20
SCHEMBL8670	0.57	9/20
SCHEMBL8856	0.53	9/20
SCHEMBL9273	0.53	9/20
SCHEMBL8931	0.51	9/20
SCHEMBL8932	0.51	9/20
SCHEMBL9163	0.58	8/20
SCHEMBL8941	0.54	8/20
SCHEMBL8047	0.56	7/20

Clinical trials — most relevant to GABRP by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effects of Ciprofol on Myocardial Injury After Non-cardiac Surgery in Video-Assisted Thoracoscopic Surgery	PHASE4	RECRUITING
Safety of Ramelteon in Elderly Subjects	PHASE4	COMPLETED
Computational Assessment of GABA Receptor Modulation in PTSD	PHASE4	RECRUITING
The Effects of Levetiracetam on Alcohol Dependent Subjects	PHASE4	COMPLETED
Safety and Efficacy Study of Ramelteon in Subjects With Chronic Insomnia	PHASE3	COMPLETED
Efficacy and Safety Study of Lamotrigine to Treat Trigeminal Neuralgia	PHASE2/PHASE3	COMPLETED
Safety and Efficacy of Ramelteon and Doxepin in Subjects With Chronic Insomnia	PHASE2	COMPLETED
Efficacy and Safety of Ramelteon Combined With Gabapentin in Treating Patients With Insomnia	PHASE2	COMPLETED
Effect of Lidocaine Transdermal Patch as Add-On Therapy in Treatment of Oxaliplatin Induced Peripheral Neuropathy in Colorectal Cancer Patients	PHASE2	UNKNOWN
Effects of Direct Transcranial Current Stimulation on Central Neural Pain Processing in Fibromyalgia	PHASE1/PHASE2	COMPLETED
Valproic Acid (VPA) for Acute Kidney Injury (AKI) in Liver Transplant Patients	PHASE2	WITHDRAWN
Diazepam Trial in GAD65 Associated Epilepsy	PHASE1/PHASE2	WITHDRAWN
Valproic Acid (VPA) for Acute Kidney Injury (AKI) in Trauma Patients	PHASE2	WITHDRAWN
Physiologic Effects of Topiramate on Cognition	PHASE1	COMPLETED
PET Imaging of Brain Peripheral Benzodiazepine Receptors	PHASE1	COMPLETED
PET Whole Body Imaging Using a Peripheral Benzodiazepine Receptor Ligand [C-11]PBR28	PHASE1	COMPLETED
Imaging the Effects of Zolpidem and Alprazolam in Healthy Volunteers at 3T	EARLY_PHASE1	UNKNOWN
MEG Study of Acute STX209 Effects in ASD	EARLY_PHASE1	COMPLETED
Association of Brain Derived Neurotrophic Factor (BDNF) rs6265 Gene Polymorphism With Susceptibility to Epilepsy	nan	UNKNOWN
Functional Study of Inhibitory Neurotransmission in the Human Epileptic Brain.	nan	RECRUITING
GABA Biomarkers in Dravet Syndrome	nan	RECRUITING
Potential Synergistic Effect of Combined Blood Flow Restriction Training and Betaine Supplementation on Skeletal Muscle	nan	COMPLETED
Mechanisms of Human Plasticity in the Human System	nan	COMPLETED
GABA/Glutamate Balance in Temporal Lobe Epilepsy With and Without Major Depression	nan	COMPLETED
Pilot Study Evaluating Neuro-Imaging Correlates of Epigenetic Finding in Prediction of Chronic Postsurgical Pain	nan	UNKNOWN
Integrins and Protocadherins in Glutamatergic Circuits: Identification of Common Signaling Pathways and Molecular Targets in Anxiety and Major Depressive Disorders (GAPsy)	nan	UNKNOWN
Comparison of the Efficacy and Safety of Ciprofol Versus Propofol for Sedation in ICU Patients Undergoing Non-Invasive Ventilation	nan	RECRUITING
The Efficacy of Tianeptine Versus Pregabalin on Acute and Chronic Post Mastectomy Pain After Breast Cancer Surgery.	nan	COMPLETED
Effect of Gabapentin on GABA Concentration and Emotional Processing	nan	COMPLETED
Oral Pregabalin Premedication for Postoperative Pain Relief	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a GABRP binder may also engage these)

Protein	Name	Similarity
Q8QZW7	—	1.000	Q8QZW7 →
Q5EA06	—	1.000	Q5EA06 →
O09028	—	0.999	O09028 →
G5EBR3	—	0.994	G5EBR3 →
Q18812	—	0.992	Q18812 →
Q9GQ00	—	0.991	Q9GQ00 →
P02710	—	0.991	P02710 →
O16926	—	0.990	O16926 →
GLRA1	Glycine receptor subunit alpha-1	0.990	landscape →
P48181	—	0.989	P48181 →
P04757	—	0.989	P04757 →
P04755	—	0.989	P04755 →
Q8R4G9	—	0.988	Q8R4G9 →
P26152	—	0.988	P26152 →
P48168	—	0.988	P48168 →
Q07263	—	0.988	Q07263 →
P18506	—	0.988	P18506 →
P20420	—	0.988	P20420 →
Q5IS75	—	0.988	Q5IS75 →
P49581	—	0.988	P49581 →
CHRNB3	Neuronal acetylcholine receptor subunit beta-	0.988	landscape →
P25162	—	0.988	P25162 →
GABRD	Gamma-aminobutyric acid receptor subunit delta	0.987	landscape →
CHRNA6	Neuronal acetylcholine receptor subunit alpha	0.987	landscape →
P02711	—	0.987	P02711 →
P17644	—	0.987	P17644 →
P22933	—	0.987	P22933 →
Q9N587	—	0.987	Q9N587 →
Q23022	—	0.987	Q23022 →
GLRB	Glycine receptor subunit beta (Glycine recept	0.986	landscape →