Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 10/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | RBP4 | P02753 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | BACE1 | P56817 | 2/20 | 0.39 |
| ▸ | HUWE1 | Q7Z6Z7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL473397 | 0.94 | AKT2 (0.44) | RPS6KB1MEN1KMT2ACSF1RRECQL | |
| SCHEMBL473361 | 0.91 | RPS6KB1 (0.55) | RPS6KB1MEN1KMT2ACSF1RALDH1A1 | |
| SCHEMBL473341 | 0.88 | PDE10A (0.45) | RPS6KB1MEN1KMT2ACSF1RALDH1A1 | |
| SCHEMBL473311 | 0.86 | MEN1 (0.50) | RPS6KB1MEN1KMT2ACSF1RALDH1A1 | |
| SCHEMBL473421 | 0.85 | MEN1 (0.54) | RPS6KB1MEN1KMT2ACSF1RALDH1A1 | |
| SCHEMBL473395 | 0.85 | RECQL (0.54) | MEN1KMT2AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL473337 | 0.85 | ALDH1A1 (0.44) | RPS6KB1MEN1KMT2ACSF1RALDH1A1 | |
| SCHEMBL473290 | 0.85 | MEN1 (0.55) | RPS6KB1MEN1KMT2AALDH1A1HTT | |
| SCHEMBL473294 | 0.84 | RECQL (0.42) | RPS6KB1MEN1KMT2ACSF1RALDH1A1 | |
| SCHEMBL473300 | 0.83 | ALDH1A1 (0.51) | MEN1KMT2ACSF1RALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848719-B1 | [1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YL]-PIPERIDINE OR -PIPERAZINE COMPOUNDS AS SERINE-THREONINE KINASE MODULATORS (P70S6K, ATK1 AND ATK2) FOR THE TREATMENT OF IMMUNOLOGICAL, INFLAMMATORY AND PROLIFERATIVE DISEASES | EXELIXIS INC (US) | 2012-02-01 | — | — | EP | disclosed |