Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 13/20 | 0.49 |
| ▸ | AKT2 | P31751 | 2/20 | 0.49 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.37 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL473310 | 0.88 | RPS6KB1 (0.52) | AKT1AKT2AKT3TSHRRPS6KB1 | |
| SCHEMBL23532317 | 0.81 | AKT1 (0.54) | AKT1AKT2AKT3RPS6KB1KIT | |
| SCHEMBL10159516 | 0.80 | AKT1 (0.38) | AKT1AKT2AKT3 | |
| SCHEMBL10158746 | 0.79 | AKT1 (0.39) | AKT1AKT2AKT3RPS6KB1 | |
| SCHEMBL473313 | 0.77 | AKT1 (0.41) | AKT1AKT2AKT3RPS6KB1 | |
| SCHEMBL23532315 | 0.74 | AKT1S1 (0.59) | AKT1AKT2AKT3RPS6KB1 | |
| SCHEMBL10157820 | 0.71 | AKT2 (0.40) | AKT1AKT2AKT3RPS6KB1 | |
| SCHEMBL390598 | 0.71 | AKT1 (0.81) | AKT1AKT2AKT3RPS6KB1 | |
| SCHEMBL1790785 | 0.71 | RPS6KB1 (0.47) | AKT1TSHRRPS6KB1KDM4EMAPT | |
| SCHEMBL25083518 | 0.71 | AKT1 (0.48) | AKT1AKT2AKT3RPS6KB1KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848719-B1 | [1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YL]-PIPERIDINE OR -PIPERAZINE COMPOUNDS AS SERINE-THREONINE KINASE MODULATORS (P70S6K, ATK1 AND ATK2) FOR THE TREATMENT OF IMMUNOLOGICAL, INFLAMMATORY AND PROLIFERATIVE DISEASES | EXELIXIS INC (US) | 2012-02-01 | — | — | EP | disclosed |