Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | G6PD | P11413 | 1/20 | 0.51 |
| ▸ | SERPINE1 | P05121 | 4/20 | 0.49 |
| ▸ | CETP | P11597 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | KLK7 | P49862 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1015269 | 0.99 | GRIK1 (0.52) | GRIK1POLBG6PDSERPINE1CETP | |
| SCHEMBL1015946 | 0.91 | SERPINE1 (0.54) | GRIK1POLBG6PDSERPINE1KDM4E | |
| SCHEMBL1015100 | 0.89 | SERPINE1 (0.55) | GRIK1POLBG6PDSERPINE1KDM4E | |
| SCHEMBL1797569 | 0.88 | SERPINE1 (0.56) | GRIK1POLBG6PDSERPINE1KDM4E | |
| SCHEMBL1015454 | 0.88 | ALDH1A1 (0.51) | CETPKDM4EGAAKLK7MAPT | |
| SCHEMBL1015137 | 0.88 | KLK7 (0.46) | GRIK1CETPGAAKLK7MAPT | |
| SCHEMBL1015619 | 0.87 | SERPINE1 (0.49) | GRIK1POLBG6PDSERPINE1CETP | |
| SCHEMBL1015626 | 0.86 | RXFP1 (0.53) | POLBG6PDSERPINE1KDM4EGAA | |
| SCHEMBL1013461 | 0.86 | SERPINE1 (0.56) | POLBG6PDSERPINE1KDM4EGAA | |
| SCHEMBL17530205 | 0.84 | KLK7 (0.47) | GRIK1POLBG6PDSERPINE1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2990057-B1 | PAI-1 INHIBITOR FOR USE IN ENHANCING THE ANTITUMOR EFFECT OF AN ANTITUMOR AGENT IN A PATIENT | RENASCIENCE CO LTD (JP) | 2019-03-20 | — | — | EP | disclosed |
| EP-2990057-A1 | NOVEL USE FOR PAI-1 INHIBITOR | Renascience Co., Ltd. (JP) | 2016-03-02 | — | — | EP | disclosed |
| EP-2272822-A1 | INHIBITOR OF PLASMINOGEN ACTIVATOR INHIBITOR-1 | Renascience CO., LTD. (JP) | 2011-01-12 | — | — | EP | disclosed |