Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
| ▸ | MMP14 | P50281 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 2/20 | 0.38 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27615947 | 0.78 | MAPT (0.47) | MAPTKMT2AKIF11NPSR1LMNA | |
| SCHEMBL4760697 | 0.72 | CYP19A1 (0.35) | — | |
| SCHEMBL28303448 | 0.72 | CYP2C9 (0.55) | MAPTCYP2C9SMN1; SMN2L3MBTL1GAA | |
| SCHEMBL10772 | 0.71 | MAPT (0.43) | MAPTKMT2ACYP2C9SMN1; SMN2L3MBTL1 | |
| SCHEMBL4558935 | 0.71 | PTPN5 (0.44) | MAPTKMT2ACYP2C9SMN1; SMN2L3MBTL1 | |
| SCHEMBL16896754 | 0.68 | MAPT (0.62) | MAPTKMT2ALMNA | |
| SCHEMBL29758021 | 0.68 | MAPT (0.57) | MAPTKMT2ACYP2C9SMN1; SMN2KIF11 | |
| SCHEMBL7379298 | 0.68 | MAPT (0.43) | MAPTKMT2ACYP2C9SMN1; SMN2L3MBTL1 | |
| SCHEMBL15302642 | 0.67 | RIPK1 (0.40) | MAPTKMT2AKIF11ALDH1A1TSHR | |
| SCHEMBL22722994 | 0.67 | CYP2C9 (0.58) | MAPTKMT2ACYP2C9SMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488489-A2 | C-LINKED HYDROXAMIC ACID DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | Pfizer Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011045703-A2 | C-LINKED HYDROXAMIC ACID DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | PFIZER INC. (US) | 2011-04-21 | — | — | WO | disclosed |