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RIPK1

Receptor-interacting serine/threonine-protein kinase 1 · Q13546 · RIPK1 on Sugi Atlas →

136,233 patent compounds predicted against RIPK1, 65,254 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL122207 SCHEMBL122207 0.61 17/20
SCHEMBL171905 SCHEMBL171905 0.47 15/20
SCHEMBL12333 SCHEMBL12333 0.50 13/20
SCHEMBL6758 SCHEMBL6758 0.38 7/20
SCHEMBL169600 SCHEMBL169600 0.36 7/20
SCHEMBL169601 SCHEMBL169601 0.36 7/20
SCHEMBL248353 SCHEMBL248353 0.61 6/20
SCHEMBL12315 SCHEMBL12315 0.50 6/20
SCHEMBL180217 SCHEMBL180217 0.47 6/20
SCHEMBL126973 SCHEMBL126973 0.42 6/20
SCHEMBL179757 SCHEMBL179757 0.66 5/20
SCHEMBL179758 SCHEMBL179758 0.66 5/20
SCHEMBL91081 SCHEMBL91081 0.61 5/20
SCHEMBL129486 SCHEMBL129486 0.52 5/20
SCHEMBL6682 SCHEMBL6682 0.37 5/20
Echinomycin Echinomycin (SCHEMBL63091) 0.32 5/20
SCHEMBL59216 SCHEMBL59216 0.56 4/20
SCHEMBL58275 SCHEMBL58275 0.55 4/20
SCHEMBL153413 SCHEMBL153413 0.51 4/20
SCHEMBL129865 SCHEMBL129865 0.51 4/20

Clinical trials — most relevant to RIPK1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
The Efficacy and Safety of Deucravacitinib in Takayasu's Arteritis PHASE4NOT_YET_RECRUITING
Clinical Study Evaluating the Anticancer Effect of Pentoxiphylline in Patients With Metastatic Colorectal Cancer PHASE4UNKNOWN
Clinical Evaluation of the Effect of Metformin in Sepsis PHASE3UNKNOWN
Ursodeoxycholic Acid as add-on Therapy in Type 2 Diabetes Mellitus PHASE2/PHASE3UNKNOWN
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus PHASE3UNKNOWN
Clinical and Genomic Responses to Open Heart Surgery PHASE3COMPLETED
The Biology of Chronic Preconditioning: Genomic and Physiologic Mechanisms of Response PHASE2UNKNOWN
MIT-001 for Prevention of CCRT-Induced OM in HNSCC Patients PHASE2ACTIVE_NOT_RECRUITING
Efficacy and Safety of Drug Combination Therapy of Isotretinoin and Some Antifungal Drugs as A Potential Aerosol Therapy for COVID-19 : An Innovative Therapeutic Approach COVID-19 PHASE2UNKNOWN
Study of Sorafenib and Docetaxel in Metastatic Prostate Cancer PHASE2COMPLETED
Pembrolizumab and Induction Chemotherapy in Head and Neck Squamous Cell Carcinoma (PICH Study) PHASE1/PHASE2WITHDRAWN
Biological Effects of Quercetin in COPD Phase II PHASE2UNKNOWN
Remote Ischaemic Conditioning in Endovascular Recanalization for Proximal Anterior Circulation Occlusion Study PHASE1UNKNOWN
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma PHASE1COMPLETED
the Influence of Remote Ischemic Preconditioning on Inflammation During Human Endotoxemia EARLY_PHASE1COMPLETED
Limb RIPC in Patients Undergoing Lung Lobectomy. Study of Oxidative Lung Damage nanCOMPLETED
Glucagon Like Peptide-1 in Remote Ischemic Conditioning nanCOMPLETED
Genetic Variation in TRAF3IP2 (rs13190932) nanRECRUITING
Remote Ischemic Preconditioning to Prevent Contrast-Induced Kidney Injury in Diabetic Patients (PRINCES) nanCOMPLETED
Effect of Periodontal Treatment on Inflammasome Proteins in Periodontal Diseases nanUNKNOWN
Molecular Mechanism of Neutrophil Necroptosis and Its Roles in RA Pathogenesis nanUNKNOWN
New Signaling Pathway Targeting Systemic Lupus Erythematosus nanUNKNOWN
ADAR1 Expression Level in Rectal Cancer nanRECRUITING
Apoptosis Markers in Aggressive Periodontitis nanCOMPLETED
Evaluation of Serum Gasdermin D Level As a Potential Biomarker of Disease Activity in Vitiligo Patients nanUNKNOWN
Probiotics and Systemic Inflammation in Patients With Metabolic Syndrome and High Cardiovascular Risk nanWITHDRAWN
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Predicting Pancreatic Necrosis Using mitDNA nanUNKNOWN
Identification of Biomarkers and Molecular Targets Involved on Intervertebral Disc Degeneration and Discogenic Pain nanUNKNOWN
Effects of Remote Ischemic Preconditioning on Restenosis Post Lower Limb Revascularization Angioplasty nanSUSPENDED

Related proteins — ESM-2 sequence neighbours (a RIPK1 binder may also engage these)

ProteinNameSimilarity
Q60855 — 0.998 Q60855 →
Q2KI79 — 0.980 Q2KI79 →
D4A7V9 — 0.979 D4A7V9 →
Q9ESL4 — 0.978 Q9ESL4 →
Q60805 — 0.977 Q60805 →
Q5NVC7 — 0.977 Q5NVC7 →
Q8WNU8 — 0.976 Q8WNU8 →
TIPARP Protein mono-ADP-ribosyltransferase TIPARP 0.976 landscape →
Q9QZ05 — 0.976 Q9QZ05 →
Q6AYH3 — 0.976 Q6AYH3 →
F1SRY5 — 0.976 F1SRY5 →
P97573 — 0.976 P97573 →
P79457 — 0.976 P79457 →
F1N5V1 — 0.976 F1N5V1 →
Q9H706 — 0.976 Q9H706 →
Q9R187 — 0.975 Q9R187 →
Q8TEW8 — 0.975 Q8TEW8 →
DDX20 Probable ATP-dependent RNA helicase DDX20 0.975 landscape →
NEK11 Serine/threonine-protein kinase Nek11 0.975 landscape →
O95999 — 0.974 O95999 →
MAP3K20 Mitogen-activated protein kinase kinase kinase 20 0.974 landscape →
Q91821 — 0.974 Q91821 →
A1L4K1 — 0.974 A1L4K1 →
Q9JJY4 — 0.974 Q9JJY4 →
Q6ZQM0 — 0.973 Q6ZQM0 →
E1C213 — 0.973 E1C213 →
A2VE78 — 0.973 A2VE78 →
A6NFN9 — 0.973 A6NFN9 →
Q8S8Y8 — 0.973 Q8S8Y8 →
O70273 — 0.973 O70273 →