Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | DVL1 | O14640 | 1/20 | 0.40 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1016816 | 0.99 | RXFP1 (0.46) | RXFP1HCAR2KDM4EPOLBLMNA | |
| SCHEMBL1015626 | 0.91 | RXFP1 (0.53) | RXFP1KDM4EPOLBLMNAALDH1A1 | |
| SCHEMBL1016922 | 0.89 | ALDH1A1 (0.43) | RXFP1KDM4ELMNAALDH1A1HSD17B10 | |
| SCHEMBL1016254 | 0.88 | ALDH1A1 (0.43) | RXFP1KDM4EPOLBLMNAALDH1A1 | |
| SCHEMBL1015634 | 0.82 | ALDH1A1 (0.53) | RXFP1KDM4EPOLBLMNAALDH1A1 | |
| SCHEMBL1799401 | 0.80 | PTPN1 (0.64) | HCAR2KDM4EPOLBALDH1A1HSD17B10 | |
| SCHEMBL1015322 | 0.80 | ALDH1A1 (0.54) | RXFP1HCAR2KDM4EPOLBLMNA | |
| SCHEMBL1798766 | 0.79 | HCAR2 (0.47) | HCAR2KDM4EPOLBALDH1A1HSD17B10 | |
| SCHEMBL1015691 | 0.79 | ALDH1A1 (0.52) | KDM4EPOLBLMNAALDH1A1HSD17B10 | |
| SCHEMBL1014577 | 0.79 | KDM4E (0.50) | HCAR2KDM4EALDH1A1HSD17B10KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2990057-B1 | PAI-1 INHIBITOR FOR USE IN ENHANCING THE ANTITUMOR EFFECT OF AN ANTITUMOR AGENT IN A PATIENT | RENASCIENCE CO LTD (JP) | 2019-03-20 | — | — | EP | disclosed |
| EP-2990057-A1 | NOVEL USE FOR PAI-1 INHIBITOR | Renascience Co., Ltd. (JP) | 2016-03-02 | — | — | EP | disclosed |
| EP-2272822-A1 | INHIBITOR OF PLASMINOGEN ACTIVATOR INHIBITOR-1 | Renascience CO., LTD. (JP) | 2011-01-12 | — | — | EP | disclosed |