Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 5/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.43 |
| ▸ | FABP4 | P15090 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10203774 | 0.86 | SLC6A2 (0.43) | SLC6A2SLC6A4FABP4HTR2AMAPT | |
| SCHEMBL11984793 | 0.82 | SLC6A2 (0.44) | SLC6A2SLC6A4FABP4HTR2AMAPT | |
| SCHEMBL10165378 | 0.82 | SLC6A2 (0.41) | SLC6A2SLC6A4FABP4HTR2AMAPT | |
| SCHEMBL14685790 | 0.79 | SLC6A2 (0.46) | SLC6A2SLC6A4FABP4HTR2A | |
| SCHEMBL10165373 | 0.74 | NOTUM (0.47) | SLC6A2SLC6A4KMT2A | |
| SCHEMBL30723538 | 0.73 | SLC6A2 (0.44) | SLC6A2SLC6A4FABP4HTR2A | |
| SCHEMBL10165383 | 0.72 | GRIN2B (0.41) | SLC6A2SLC6A4 | |
| SCHEMBL10165448 | 0.69 | KMT2A (0.41) | MAPTKDM4EKMT2AGAAMEN1 | |
| SCHEMBL24110494 | 0.68 | FABP4 (0.38) | SLC6A2SLC6A4FABP4KMT2ACES2 | |
| SCHEMBL24110356 | 0.68 | FABP4 (0.38) | SLC6A2SLC6A4FABP4KMT2ACES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8193194-B2 | Ion channel modulators and methods of use | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-05 | — | — | US | disclosed |
| US-8193194-B2 | Ion channel modulators and methods of use | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-05 | — | — | US | disclosed |