Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8014355 | 1.00 | HDAC4 (0.56) | HDAC4HRH3ALDH1A1SLC9A1SIGMAR1 | |
| SCHEMBL8088723 | 1.00 | HDAC4 (0.56) | HDAC4HRH3ALDH1A1SLC9A1SIGMAR1 | |
| SCHEMBL29296459 | 1.00 | HDAC4 (0.56) | HDAC4HRH3ALDH1A1SLC9A1SIGMAR1 | |
| SCHEMBL14012771 | 1.00 | HDAC4 (0.56) | HDAC4HRH3ALDH1A1SLC9A1SIGMAR1 | |
| SCHEMBL15113836 | 0.81 | KCNQ3 (0.61) | HRH3HPGDKDM1A | |
| SCHEMBL17087684 | 0.80 | BACE1 (0.52) | HRH3SIGMAR1KDM1A | |
| SCHEMBL13301231 | 0.79 | HDAC4 (0.61) | HDAC4HRH3ALDH1A1SLC9A1SIGMAR1 | |
| SCHEMBL15030617 | 0.79 | HDAC4 (0.61) | HDAC4HRH3ALDH1A1SLC9A1SIGMAR1 | |
| SCHEMBL4751 | 0.79 | HDAC4 (0.61) | HDAC4HRH3ALDH1A1SLC9A1SIGMAR1 | |
| SCHEMBL6997217 | 0.79 | HDAC4 (0.61) | HDAC4HRH3ALDH1A1SLC9A1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11732005-B2 | Peptidomimetic proteasome inhibitors | CORNELL UNIVERSITY (US) | 2023-08-22 | — | — | US | disclosed |
| US-20220056073-A1 | PEPTIDOMIMETIC PROTEASOME INHIBITORS | UNIV CORNELL (US) | 2022-02-24 | — | — | US | disclosed |
| US-20120035194-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | PFIZER INC. (US) | 2012-02-09 | — | — | US | disclosed |
| US-7998978-B2 | Substituted 2-amino-fused heterocyclic compounds | PFIZER INC. (US) | 2011-08-16 | — | — | US | disclosed |
| US-20100056506-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220056073-A1 | PEPTIDOMIMETIC PROTEASOME INHIBITORS | PSMB1, PSMB3, PSMB11 | HDAC4 563/4885HRH3 1793/4885ALDH1A1 4635/4885 |
| US-20120035194-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | MAPK1, SLC5A1, ATF1 | HDAC4 621/4885HRH3 1634/4885ALDH1A1 1098/4885 |
| US-20100056506-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | MAPK1, SLC5A1, ATF1 | HDAC4 621/4885HRH3 1634/4885ALDH1A1 1098/4885 |
| US-11732005-B2 | Peptidomimetic proteasome inhibitors | PSMB1, PSMB3, PSMB11 | HDAC4 563/4885HRH3 1793/4885ALDH1A1 4635/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.