Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 15/20 | 0.79 |
| ▸ | MPO | P05164 | 1/20 | 0.79 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.75 |
| ▸ | TP53 | P04637 | 5/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 3/20 | 0.64 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | CASP1 | P29466 | 1/20 | 0.60 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL430097 | 0.92 | ADORA2A (0.82) | MAPTMPOADORA2ATP53ALDH1A1 | |
| SCHEMBL427153 | 0.91 | ADORA2A (0.82) | MAPTMPOADORA2ATP53ALDH1A1 | |
| SCHEMBL432028 | 0.89 | MAPT (1.00) | MAPTMPOADORA2ATP53ALDH1A1 | |
| SCHEMBL424745 | 0.89 | TDP1 (0.74) | MAPTMPOADORA2ATP53ALDH1A1 | |
| SCHEMBL425121 | 0.87 | MAPT (0.71) | MAPTMPOADORA2ATP53ALDH1A1 | |
| SCHEMBL428923 | 0.86 | ADORA2A (0.80) | MAPTMPOADORA2ATP53ALDH1A1 | |
| SCHEMBL430160 | 0.86 | ADORA2A (1.00) | MAPTMPOADORA2ATP53ALDH1A1 | |
| SCHEMBL430301 | 0.86 | ADORA2A (0.83) | MAPTMPOADORA2ATP53ALDH1A1 | |
| SCHEMBL425455 | 0.85 | ADORA2A (0.82) | MAPTMPOADORA2ATP53ALDH1A1 | |
| SCHEMBL430882 | 0.85 | MAPT (1.00) | MAPTMPOADORA2ATP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120022046-A1 | Thienopyridine Derivatives for the Treatment and Prevention of Dengue Virus Infections | SIGA TECHNOLOGIES, INC. | 2012-01-26 | — | — | US | disclosed |
| WO-2010099166-A1 | THIENOPYRIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS | SIGA TECHNOLOGIES, INC. (US) | 2010-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022046-A1 | Thienopyridine Derivatives for the Treatment and Prevention of Dengue Virus Infections | TTPA, TPMT, SLC19A2 | MAPT 138/4885MPO 2720/4885ADORA2A 355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.