TTPA — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL3935483	0.38	5/20
SCHEMBL7825046	0.56	4/20
SCHEMBL7836352	0.56	4/20
SCHEMBL7835312	0.55	4/20
SCHEMBL7836231	0.55	4/20
SCHEMBL7826804	0.54	4/20
SCHEMBL7833220	0.53	4/20
SCHEMBL7835707	0.53	4/20
SCHEMBL7836663	0.53	4/20
Dimethylamine (SCHEMBL8131335)	0.53	4/20
SCHEMBL2393313	0.52	4/20
SCHEMBL7836851	0.51	4/20
SCHEMBL8377650	0.51	4/20
Bromide (SCHEMBL5805100)	0.51	4/20
SCHEMBL3027394	0.49	4/20
Hydrochloric Acid (SCHEMBL3151645)	0.48	4/20
Hydrochloric Acid (SCHEMBL3155208)	0.47	4/20
SCHEMBL2140130	0.43	4/20
SCHEMBL2140140	0.43	4/20
Alpha-Tocopherol (SCHEMBL3097)	1.00	3/20

Clinical trials — most relevant to TTPA by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Type 2 Diabetes Haptoglobin Phenotype and Vitamin E	PHASE2/PHASE3	COMPLETED
Efficacy and Safety of Carica Papaya in Dengue Fever: A Randomised Clinical Trial	PHASE3	COMPLETED
Role of Vitamin E in Gaucher Disease Patients	PHASE3	COMPLETED
Vitamin E and DHA-EE on NAFLD - Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Clinical Trial (PUVENAFLD)	PHASE2	COMPLETED
Effect of Gamma Tocopherol Enriched Supplementation on Response to Inhaled O3 Exposure	PHASE2	COMPLETED
Evaluation of Antioxidant Activity of Oral Lutein in Preterm and Term Newborn	PHASE1/PHASE2	COMPLETED
Lipoic Acid Supplement for Cystine Stone	PHASE2	COMPLETED
NEO100 and High-Grade Meningioma	PHASE2	RECRUITING
Oxidative Stress and Vitamin E Requirements	PHASE2	COMPLETED
Effect of High Dose Vitamin E on Carotid Atherosclerosis	PHASE2	COMPLETED
Vitamin E Pharmacokinetics and Biomarkers in Normal and Obese Women	PHASE1	COMPLETED
Vitamin E δ-Tocotrienol (VEDT) Single Dose in Healthy Subjects	PHASE1	COMPLETED
Human Tissue Distribution of Orally Supplemented Natural Vitamin E Tocotrienol	EARLY_PHASE1	COMPLETED
Relationship of Haptoglobin Phenotype to Vascular Function and Response to Vitamin E Supplementation in Patients With Diabetes Mellitus Type 2: The EVAS Trial	nan	UNKNOWN
Personalizing Preterm Neonatal Transfusions With Fetal Hemoglobin-Enriched Cord Blood	nan	NOT_YET_RECRUITING
The Effect of Alpha-tocopherol in Hemolysis and Oxidative Stress Marker on the Red Cell Membrane Beta-thalassemia Major	nan	COMPLETED
Evaluation of the Effect of Alpha Lipoic Acid on Radiation Induced Dermatitis in Breast Cancer Patients	nan	RECRUITING
Thiol/Disulphide Homeostasis in Unexplained Infertility	nan	COMPLETED
Effects of TIVA and Inhalation Anesthesia on Oxidative Stress Factors During Hypotensive Anesthesia	nan	COMPLETED
The Correlation Between Vitamin A / E Levels and Preeclampsia	nan	UNKNOWN
Reactive Oxygen Species Following Aortic Valve Replacement	nan	COMPLETED
Role of Vitamin C Infusion in Postoperative Mechanically Ventilated Neonates With Sepsis	nan	COMPLETED
Cardiovascular Risk Factors, Lipid Metabolism and Oxidative Stress	nan	UNKNOWN
Development of Biomarker for Development of Non-Alcoholic Steatohepatitis (NASH) in Children	nan	WITHDRAWN
Role of Hazelnut Consumption in Improving Micronutrient Status in Older Adults	nan	COMPLETED
Evaluation of a Short Course of Gamma Tocopherol Supplementation in Adult Subjects	nan	COMPLETED
The Effect of Topical Almond Oil vs. Topical Retinol on The Appearance of Facial Wrinkles	nan	COMPLETED
Effect of a Black Garlic Extract on Cholesterol LDL Levels	nan	COMPLETED
Effects of Xoçai Antioxidant Supplements on Atherosclerosis Risk Factors	nan	COMPLETED
Vitamin E Supplementation for Children With Transfusion Dependent Beta Thalassemia on Different Iron Chelation Regimen	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a TTPA binder may also engage these)

Protein	Name	Similarity
P41034	—	0.994	P41034 →
Q8BWP5	—	0.990	Q8BWP5 →
Q9D4C9	—	0.956	Q9D4C9 →
Q8BG92	—	0.952	Q8BG92 →
A6JFQ6	—	0.951	A6JFQ6 →
Q5RCA6	—	0.951	Q5RCA6 →
Q2KIX2	—	0.951	Q2KIX2 →
Q9NXN4	—	0.951	Q9NXN4 →
Q5SYC1	—	0.950	Q5SYC1 →
Q5M7E1	—	0.950	Q5M7E1 →
Q95KF7	—	0.949	Q95KF7 →
Q8IUQ0	—	0.949	Q8IUQ0 →
Q4R678	—	0.949	Q4R678 →
A6JUQ6	—	0.947	A6JUQ6 →
Q5CZL1	—	0.947	Q5CZL1 →
Q66H63	—	0.947	Q66H63 →
Q9DBL2	—	0.946	Q9DBL2 →
Q5XGM5	—	0.943	Q5XGM5 →
Q5SPP0	—	0.942	Q5SPP0 →
Q9UI17	—	0.940	Q9UI17 →
Q66HX8	—	0.939	Q66HX8 →
Q99797	—	0.937	Q99797 →
Q64421	—	0.937	Q64421 →
LPCAT1	Lysophosphatidylcholine acyltransferase 1	0.937	landscape →
Q8N3Z3	—	0.937	Q8N3Z3 →
A6H611	—	0.936	A6H611 →
Q03113	—	0.936	Q03113 →
Q5RE14	—	0.935	Q5RE14 →
Q60555	—	0.935	Q60555 →
O95671	—	0.935	O95671 →