Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.38 |
| ▸ | SCN3A | Q9NY46 | 6/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.36 |
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.34 |
| ▸ | SCN1A | P35498 | 1/20 | 0.34 |
| ▸ | SCN4A | P35499 | 1/20 | 0.34 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.34 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | YAP1 | P46937 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL483562 | 0.90 | KCNH2 (0.48) | KCNH2SCN3AADAM17BTKSCN1A | |
| SCHEMBL310836 | 0.90 | KCNH2 (0.48) | KCNH2SCN3AADAM17BTKSCN1A | |
| SCHEMBL483666 | 0.88 | KCNH2 (0.45) | KCNH2SCN3AADAM17MAOB | |
| SCHEMBL484165 | 0.85 | SCN3A (0.48) | KCNH2SCN3AADAM17BTKSCN1A | |
| SCHEMBL483702 | 0.85 | SCN3A (0.48) | KCNH2SCN3AADAM17BTKSCN1A | |
| SCHEMBL10167514 | 0.82 | KCNH2 (0.42) | KCNH2SCN3AADAM17BTKSCN1A | |
| SCHEMBL483138 | 0.81 | DDB1 (0.36) | — | |
| SCHEMBL310424 | 0.81 | DDB1 (0.36) | — | |
| SCHEMBL483533 | 0.81 | F2 (0.39) | KCNH2SCN3ABTKSCN1ASCN4A | |
| SCHEMBL13133690 | 0.80 | GPR119 (0.38) | KCNH2SCN3ABTKSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934176-B1 | QUATERNARY ALPHA-AMINOCARBOXAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | GLAXO GROUP LTD (GB) | 2012-02-01 | — | — | EP | disclosed |