Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | USP8 | P40818 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | RPA1 | P27694 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10167894 | 0.82 | MAPT (0.54) | MAPTNPC1RAB9AUSP8GAA | |
| SCHEMBL10168067 | 0.81 | MAPT (0.53) | MAPTNPC1RAB9AUSP8GAA | |
| SCHEMBL630468 | 0.81 | MAPT (0.53) | MAPTNPC1RAB9AUSP8GAA | |
| SCHEMBL13902032 | 0.79 | MAPT (0.51) | MAPTNPC1RAB9AUSP8GAA | |
| SCHEMBL10168248 | 0.79 | MAPT (0.51) | MAPTNPC1RAB9AUSP8GAA | |
| SCHEMBL13901964 | 0.77 | USP8 (0.52) | MAPTNPC1RAB9AUSP8GAA | |
| SCHEMBL10168237 | 0.76 | USP8 (0.48) | MAPTNPC1RAB9AUSP8GAA | |
| SCHEMBL14495190 | 0.75 | USP8 (0.50) | MAPTNPC1RAB9AUSP8GAA | |
| SCHEMBL15070234 | 0.74 | USP8 (0.49) | MAPTNPC1RAB9AUSP8GAA | |
| SCHEMBL13902189 | 0.74 | RPA1 (0.65) | MAPTNPC1RAB9AUSP8RPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534680-B1 | PRENYLATION INHIBITORS AND METHODS OF THEIR SYNTHESIS AND USE | PHARMACO INVESTMENTS INC (US) | 2012-02-22 | — | — | EP | disclosed |