Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP8 | P40818 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | RPA1 | P27694 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.39 |
| ▸ | FABP3 | P05413 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13901964 | 0.93 | USP8 (0.52) | USP8NPC1MAPTRAB9ACA12 | |
| SCHEMBL15070232 | 0.87 | CYP3A4 (0.56) | USP8NPC1MAPTRAB9ACA12 | |
| SCHEMBL10168238 | 0.85 | MKNK1 (0.55) | USP8NPC1MAPTRAB9ARPA1 | |
| SCHEMBL15070407 | 0.85 | USP8 (0.44) | USP8NPC1MAPTRAB9ACA12 | |
| SCHEMBL14626195 | 0.84 | MKNK1 (0.43) | USP8NPC1MAPTRAB9ARPA1 | |
| SCHEMBL15070234 | 0.83 | USP8 (0.49) | USP8NPC1MAPTRAB9ACA12 | |
| SCHEMBL13902067 | 0.79 | HPGDS (0.45) | USP8NPC1MAPTRAB9ARPA1 | |
| SCHEMBL13902340 | 0.79 | HDAC3 (0.43) | USP8NPC1MAPTRAB9ARPA1 | |
| SCHEMBL10167894 | 0.78 | MAPT (0.54) | USP8NPC1MAPTRAB9ACA12 | |
| SCHEMBL13902368 | 0.77 | GGT1 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534680-B1 | PRENYLATION INHIBITORS AND METHODS OF THEIR SYNTHESIS AND USE | PHARMACO INVESTMENTS INC (US) | 2012-02-22 | — | — | EP | disclosed |