Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 12/20 | 0.41 |
| ▸ | RORC | P51449 | 7/20 | 0.35 |
| ▸ | IL1B | P01584 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8125277 | 0.92 | P2RX7 (0.44) | P2RX7IL1B | |
| SCHEMBL10169770 | 0.91 | P2RX7 (0.41) | P2RX7RORCIL1B | |
| SCHEMBL8139317 | 0.89 | P2RX7 (0.46) | P2RX7IL1B | |
| SCHEMBL10169766 | 0.88 | P2RX7 (0.40) | P2RX7IL1B | |
| SCHEMBL8125278 | 0.85 | P2RX7 (0.52) | P2RX7IL1B | |
| SCHEMBL10169769 | 0.84 | P2RX7 (0.40) | P2RX7 | |
| SCHEMBL8127028 | 0.84 | P2RX7 (0.45) | P2RX7 | |
| SCHEMBL10169774 | 0.83 | P2RX7 (0.45) | P2RX7IL1B | |
| SCHEMBL8139994 | 0.83 | P2RX7 (0.44) | P2RX7IL1B | |
| SCHEMBL306309 | 0.82 | P2RX7 (0.41) | P2RX7RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093265-B2 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | RENOVIS, INC. (US) | 2012-01-10 | — | — | US | disclosed |