Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27676185 | 0.87 | GRIA2 (0.44) | RECQLALDH1A1KDM4EPOLBADCY10 | |
| SCHEMBL4685142 | 0.83 | SCN9A (0.42) | SMN1; SMN2ALDH1A1KDM4EGRM5LMNA | |
| SCHEMBL23566756 | 0.79 | TSHR (0.51) | SMN1; SMN2ALDH1A1KDM4EHPGDADORA3 | |
| SCHEMBL10960207 | 0.79 | KDM4E (0.49) | SMN1; SMN2RECQLALDH1A1KDM4EPOLB | |
| SCHEMBL23401443 | 0.79 | SMN1; SMN2 (0.51) | SMN1; SMN2RECQLALDH1A1KDM4EPOLB | |
| SCHEMBL10956243 | 0.79 | KDM4E (0.49) | SMN1; SMN2RECQLALDH1A1KDM4EPOLB | |
| SCHEMBL11708100 | 0.78 | SMN1; SMN2 (0.50) | SMN1; SMN2RECQLALDH1A1KDM4EPOLB | |
| SCHEMBL8842415 | 0.78 | CDK8 (0.56) | SMN1; SMN2RECQLALDH1A1KDM4EPOLB | |
| SCHEMBL16381208 | 0.77 | SMN1; SMN2 (0.49) | SMN1; SMN2RECQLALDH1A1KDM4EPOLB | |
| SCHEMBL14191068 | 0.76 | NPSR1 (0.66) | SMN1; SMN2RECQLALDH1A1POLBNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148363-B2 | Heterocyclic compounds as factor IXA inhibitors | SCHERING CORPORATION (US) | 2012-04-03 | — | — | US | disclosed |
| US-20110065682-A1 | HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS | MERCK SHARP & DOHME LLC | 2011-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110065682-A1 | HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS | F9, F12, F8 | SMN1; SMN2 3004/4885RECQL 1611/4885ALDH1A1 1022/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.