Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10958929 | 0.84 | TP53 (0.57) | KDM4EALDH1A1POLBHPGDCSF1R | |
| SCHEMBL10960207 | 0.83 | KDM4E (0.49) | KDM4EALDH1A1POLBHPGDCSF1R | |
| SCHEMBL8842415 | 0.81 | CDK8 (0.56) | KDM4EALDH1A1POLBHPGDCSF1R | |
| SCHEMBL8842670 | 0.81 | BCL2 (0.49) | KDM4EALDH1A1POLBFGFR1RECQL | |
| SCHEMBL10960698 | 0.80 | ALDH1A1 (0.45) | KDM4EALDH1A1HPGDLMNAMEN1 | |
| SCHEMBL10140393 | 0.79 | TP53 (0.48) | KDM4EALDH1A1POLBHPGDCSF1R | |
| SCHEMBL10172743 | 0.79 | SMN1; SMN2 (0.48) | KDM4EALDH1A1POLBHPGDCSF1R | |
| SCHEMBL11674731 | 0.78 | MEN1 (0.50) | KDM4EALDH1A1POLBHPGDCSF1R | |
| SCHEMBL30835649 | 0.78 | KDM4E (0.47) | KDM4EALDH1A1POLBHPGDCSF1R | |
| SCHEMBL23402462 | 0.77 | RECQL (0.46) | KDM4EALDH1A1POLBCSF1RFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2805939-A1 | Heterocyclic compounds as factor IXA inhibitors. | Merck Sharp & Dohme Corp. (US) | 2014-11-26 | — | — | EP | disclosed |
| US-4495195-A | ANTI-GOUT, ANTI-GOUTY ARTHRITIS AGENTS | ELI LILLY AND COMPANY (US) | 1985-01-22 | — | — | US | disclosed |
| EP-0112623-A2 | 3-Aryl-5-pyrazole-carboxylic-acid derivatives, their preparation and pharmaceutical compositions | ELI LILLY AND COMPANY (US) | 1984-07-04 | — | — | EP | disclosed |