Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.31 |
| ▸ | DRD1 | P21728 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18199654 | 0.94 | GBA1 (0.38) | GBA1LMNADRD2DRD1MEN1 | |
| SCHEMBL15471354 | 0.94 | GBA1 (0.38) | GBA1LMNADRD2DRD1MEN1 | |
| SCHEMBL24926332 | 0.94 | GBA1 (0.38) | GBA1LMNADRD2DRD1MEN1 | |
| SCHEMBL10172780 | 0.89 | GBA2 (0.40) | GBA1MAOBHRH3S1PR1S1PR3 | |
| SCHEMBL25959090 | 0.87 | S1PR1 (0.41) | GBA1S1PR1S1PR3S1PR5GAA | |
| SCHEMBL5989865 | 0.83 | ALDH1A1 (0.31) | MAOBHRH3 | |
| SCHEMBL18963699 | 0.82 | GBA1 (0.36) | GBA1LMNAKCNK3S1PR1S1PR3 | |
| SCHEMBL24926283 | 0.82 | GBA2 (0.41) | GBA1S1PR1S1PR3S1PR5GAA | |
| SCHEMBL24926618 | 0.81 | S1PR1 (0.44) | GBA1S1PR1S1PR3S1PR5GAA | |
| SCHEMBL24926672 | 0.79 | S1PR1 (0.47) | GBA1S1PR1S1PR3S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120021519-A1 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2012-01-26 | — | — | US | disclosed |