Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 3/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | ELANE | P08246 | 13/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | CASR | P41180 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1161604 | 0.85 | PIK3CD (0.50) | PIK3CDELANEPARP1CASRPIK3CG | |
| SCHEMBL735504 | 0.80 | PIK3CD (0.73) | PIK3CDPIK3CG | |
| SCHEMBL19520455 | 0.80 | PIK3CD (0.46) | PIK3CDELANEPARP1CASRPIK3CG | |
| SCHEMBL7013206 | 0.80 | SMN1; SMN2 (0.49) | PIK3CDELANEPARP1CASR | |
| SCHEMBL7014708 | 0.79 | ELANE (0.49) | PIK3CDELANEPARP1CASR | |
| SCHEMBL4159984 | 0.78 | NPC1 (0.44) | CDK1CCNB1CCNE1CDK2CASR | |
| SCHEMBL734003 | 0.77 | PIK3CD (0.61) | PIK3CDPIK3CG | |
| SCHEMBL1161498 | 0.76 | HDAC6 (0.64) | CDK1CCNB1CCNE1CDK2 | |
| SCHEMBL7011912 | 0.76 | ELANE (0.46) | PIK3CDELANEPARP1CASR | |
| SCHEMBL29571733 | 0.76 | HDAC6 (0.64) | CDK1CCNB1CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138195-B2 | Inhibitors of human phosphatidylinositol 3-kinase delta | ICOS CORPORATION (US) | 2012-03-20 | — | — | US | disclosed |