Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 12/20 | 0.55 |
| ▸ | CYP11B1 | P15538 | 11/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 3/20 | 0.41 |
| ▸ | JAK1 | P23458 | 3/20 | 0.41 |
| ▸ | TYK2 | P29597 | 3/20 | 0.41 |
| ▸ | JAK3 | P52333 | 3/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17896595 | 0.77 | CYP11B2 (0.69) | CYP11B2CYP11B1CYP19A1ADRA2B | |
| SCHEMBL459504 | 0.73 | CYP11B2 (0.56) | CYP11B2CYP11B1CYP19A1JAK2JAK1 | |
| SCHEMBL17896682 | 0.73 | CYP11B2 (0.63) | CYP11B2CYP11B1CYP19A1ADRA2B | |
| SCHEMBL431567 | 0.72 | CYP11B2 (0.67) | CYP11B2CYP11B1CYP19A1ADRA2B | |
| SCHEMBL20338392 | 0.71 | CYP11B2 (1.00) | CYP11B2CYP11B1 | |
| SCHEMBL17896765 | 0.67 | CYP11B2 (0.58) | CYP11B2CYP11B1KDM4E | |
| SCHEMBL17896590 | 0.66 | CYP11B2 (0.75) | CYP11B2CYP11B1 | |
| SCHEMBL17883792 | 0.66 | CYP11B2 (0.58) | CYP11B2CYP11B1CYP19A1ADRA2B | |
| SCHEMBL17896599 | 0.66 | CYP11B2 (0.63) | CYP11B2CYP11B1CYP19A1ADRA2B | |
| SCHEMBL17896766 | 0.65 | CYP11B2 (0.43) | CYP11B2CYP11B1CYP19A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012012478-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | disclosed |